Novel pegiviruses infecting wild birds and rodents

Wentao Zhu; Jing Yang; Shan Lu; Yuyuan Huang; Dong Jin; Ji Pu; Liyun Liu; Zhenjun Li; Mang Shi; Jianguo Xu

doi:10.1016/j.virs.2022.01.013

April 2022

Wentao Zhu, Jing Yang, Shan Lu, Yuyuan Huang, Dong Jin, Ji Pu, Liyun Liu, Zhenjun Li, Mang Shi and Jianguo Xu. Novel pegiviruses infecting wild birds and rodents[J]. Virologica Sinica, 2022, 37(2): 208-214. doi: 10.1016/j.virs.2022.01.013

Citation: Wentao Zhu, Jing Yang, Shan Lu, Yuyuan Huang, Dong Jin, Ji Pu, Liyun Liu, Zhenjun Li, Mang Shi, Jianguo Xu. Novel pegiviruses infecting wild birds and rodents .VIROLOGICA SINICA, 2022, 37(2) : 208-214. http://dx.doi.org/10.1016/j.virs.2022.01.013

感染野生鸟类和啮齿类动物的新pegivirus

朱文涛 ^a ,
杨晶 ^a,b,c ,
卢珊 ^a,b,c ,
黄虞远 ^a ,
金东 ^a,b,c ,
濮吉 ^a ,
刘丽云 ^a,c ,
李振军 ^a ,
施莽 ^d,, ,
徐建国 ^a,b,c,e,,

1. 中国疾控中心传染病所
2. 上海市公共卫生临床中心
3. 中国医学科学院
4. 中山大学医学院(深圳)
5. 南开大学公共卫生与健康研究院

通讯作者： 施莽, shim23@mail.sysu.edu.cn; 徐建国, xujianguo@icdc.cn
收稿日期： 2021-08-30
录用日期： 2021-11-04

摘要

Pegivirus是黄病毒科（Flaviviridae）的一个包膜RNA病毒属，主要引起包括人在内的各种哺乳动物的血液感染。本文主要对来源于青藏高原的多种野生动物携带的pegivirus进行调查研究。我们从不同的野生鸟类呼吸道中鉴定到了三种新的病毒，命名为麻雀pegivirus （Passer montanus pegivirus），高山岭雀pegivirus (Leucosticte brandti pegivirus)和白腰雪雀pegivirus (Montifringilla taczanowskii pegivirus), 以及从白尾松田鼠中鉴定到一种新的啮齿类pegivirus，命名为白尾松田鼠pegivirus (Phaiomys leucurus pegivirus)。有意思的是，之前的报道显示pegivirus绝大多数都是来源哺乳动物；本文发现的非哺乳动物起源（来自鸟类）的病毒极大地扩展了pegivirus的宿主范围。另外，共进化显示pegivirus与它们的宿主在漫长的进化史上保持了共进化状态，也就是说pegivirus在很大程度上遵循病毒与宿主共同进化的关系，因此可将所有pegivirus的共同进化祖先追溯到312百万年前。总之，本研究首次报道了多个感染野生鸟类的pegivirus，扩展了它们的多样性，并因此可能改写pegevirus的宿主范围以及进化历史。
- 鸟
- , 鼠
- , pegivirus
- , 进化
- , 青藏高原

Novel pegiviruses infecting wild birds and rodents

Wentao Zhu ^a ,
Jing Yang ^a,b,c ,
Shan Lu ^a,b,c ,
Yuyuan Huang ^a ,
Dong Jin ^a,b,c ,
Ji Pu ^a ,
Liyun Liu ^a,c ,
Zhenjun Li ^a ,
Mang Shi ^d,, ,
Jianguo Xu ^a,b,c,e,,

a State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China
b Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China
c Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, 100730, China
d School of Medicine, Sun Yat-sen University, Shenzhen, 510006, China
e Research Institute of Public Heath, Nankai University, Tianjin, 300071, China

Corresponding author: Mang Shi, shim23@mail.sysu.edu.cn Jianguo Xu, xujianguo@icdc.cn
Received Date: 30 August 2021
Accepted Date: 04 November 2021

Abstract

Pegivirus (family Flaviviridae) is a genus of small enveloped RNA viruses that mainly causes blood infections in various mammals including human. Herein, we carried out an extensive survey of pegiviruses from a wide range of wild animals mainly sampled in the Qinghai-Tibet Plateau of China. Three novel pegiviruses, namely Passer montanus pegivirus, Leucosticte brandti pegivirus and Montifringilla taczanowskii pegivirus, were identified from different wild birds, and one new rodent pegivirus, namely Phaiomys leucurus pegivirus, was identified from Blyth's vole. Interestingly, the pegiviruses of non-mammalian origin discovered in this study substantially broaden the host range of Pegivirus to avian species. Co-evolutionary analysis showed virus-host co-divergence over long evolutionary timescales, and indicated that pegiviruses largely followed a virus-host co-divergence relationship. Overall, this work extends the biodiversity of the Pegivirus genus to those infecting wild birds and hence revises the host range and evolutionary history of genus Pegivirus.
- Bird
- , Rat
- , Pegivirus
- , Evolution
- , Qinghai-Tibet Plateau

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Electronic Supplementary Material

10.1016j.virs.2022.01.013-ESM.docx