Saliva-based point-of-care testing techniques for COVID-19 detection

Shiwen Wang; Ying Liu; Yang Qiu; Qian Dou; Yang Han; Muhan Huang; Ke Hong; Bei Yang; Xi Zhou; Qing Dai

doi:10.1016/j.virs.2022.04.004

June 2022

Shiwen Wang, Ying Liu, Yang Qiu, Qian Dou, Yang Han, Muhan Huang, Ke Hong, Bei Yang, Xi Zhou and Qing Dai. Saliva-based point-of-care testing techniques for COVID-19 detection[J]. Virologica Sinica, 2022, 37(3): 472-476. doi: 10.1016/j.virs.2022.04.004

Citation: Shiwen Wang, Ying Liu, Yang Qiu, Qian Dou, Yang Han, Muhan Huang, Ke Hong, Bei Yang, Xi Zhou, Qing Dai. Saliva-based point-of-care testing techniques for COVID-19 detection .VIROLOGICA SINICA, 2022, 37(3) : 472-476. http://dx.doi.org/10.1016/j.virs.2022.04.004

基于唾液即时检测技术在COVID-19中的应用

汪诗文 ^a,b ,
刘颖 ^d ,
邱洋 ^c ,
窦倩 ^a,e ,
韩阳 ^c,d ,
黄霂晗 ^c ,
洪可 ^d ,
杨贝 ^a,e,, ,
周溪 ^c,d,, ,
戴庆 ^a,e,,

1. 中国科学院纳米光子材料与器件重点实验室、中国科学院纳米技术标准化与测量重点实验室、中国科学院纳米科学卓越中心、国家纳米科学技术中心, 北京, 100190;
2. 天津大学理学院化学系分子光电子科学天津重点实验室, 天津, 300072;
3. 中国科学院生物安全超级科学中心武汉病毒学研究所病毒学国家重点实验室, 武汉, 430071;
4. 武汉病毒研究所与武汉金银滩医院传染病与健康联合实验室, 武汉金银滩医院, 武汉, 430048;
5. 中国科学院材料科学与光电工程中心, 北京, 100049, 中国

通讯作者： 杨贝, yangb2020@nanoctr.cn; 周溪, zhouxi@wh.iov.cn; 戴庆, daiq@nanoctr.cn
收稿日期： 2021-09-02
录用日期： 2022-03-30

摘要

唾液是一个丰富的生物样本库，包含了蛋白质、DNA/RNA、激素和微生物等生物分子。更重要的是，唾液采集方便，无需任何专业医疗技能，可由受试者独自进行。这些优点使唾液能够在家中、野外、护理点等场景随时随地被收集和检测，使其成为开发相关护理点检测（POCT）技术媒介的完美候选。POCT是指在采样现场进行的、利用便携式分析仪器及配套试剂快速得到检测结果的一种检测方式，通常不一定是临床检验师来进行，省去了样本在实验室检测时的复杂处理程序。因此，基于唾液的POCT设备一旦得到良好的集成和开发，将会为患者提供一个简单、便携式和用户友好的平台，在大规模的流行病筛查、疾病自我诊断和日常健康监测等场景下展现出极其重要的应用前景。
- 唾液
- , 即时诊断
- , 新型冠状肺炎

Saliva-based point-of-care testing techniques for COVID-19 detection

Shiwen Wang ^a,b ,
Ying Liu ^d ,
Yang Qiu ^c ,
Qian Dou ^a,e ,
Yang Han ^c,d ,
Muhan Huang ^c ,
Ke Hong ^d ,
Bei Yang ^a,e,, ,
Xi Zhou ^c,d,, ,
Qing Dai ^a,e,,

a CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China;
b Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin, 300072, China;
c State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China;
d Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, Wuhan Jinyintan Hospital, Wuhan, 430048, China;
e Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China

Corresponding author: Bei Yang, yangb2020@nanoctr.cn Xi Zhou, zhouxi@wh.iov.cn Qing Dai, daiq@nanoctr.cn
Received Date: 02 September 2021
Accepted Date: 30 March 2022

Abstract

Highlights
1. The advantages of COVID-19 detection in saliva were systematically introduced.
2. Saliva-based POCT technologies for the detection of COVID-19 were reviewed.
3. A positive correlation between COVID-19 antibodies in saliva and serum was demonstrated.

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Electronic Supplementary Material

10.1016j.virs.2022.04.004-ESM.docx