Najealicka Armstrong and Qiyi Tang. Congenital cytomegalovirus infection and advances in murine models of neuropathogenesis[J]. Virologica Sinica, 2022, 37(2): 318-320. doi: 10.1016/j.virs.2022.04.007
Citation: Najealicka Armstrong, Qiyi Tang. Congenital cytomegalovirus infection and advances in murine models of neuropathogenesis .VIROLOGICA SINICA, 2022, 37(2) : 318-320.  http://dx.doi.org/10.1016/j.virs.2022.04.007

Congenital cytomegalovirus infection and advances in murine models of neuropathogenesis

  • 通讯作者: Qiyi Tang, qiyi.tang@howard.edu
  • 收稿日期: 2022-02-11
    录用日期: 2022-03-23
  • Highlights
    · Congenital human cytomegalovirus (CMV) infection causes severe neuropathogenesis.
    · Murine CMV failed to break through the placental barrier to transmit to fetus.
    · Zhou et al. established a novel mouse system to model congenital HCMV infection.
    · The mouse CMV system by Zhou et al can be used for drug screening.

Congenital cytomegalovirus infection and advances in murine models of neuropathogenesis

  • Corresponding author: Qiyi Tang, qiyi.tang@howard.edu
  • Received Date: 11 February 2022
    Accepted Date: 23 March 2022
  • Highlights
    · Congenital human cytomegalovirus (CMV) infection causes severe neuropathogenesis.
    · Murine CMV failed to break through the placental barrier to transmit to fetus.
    · Zhou et al. established a novel mouse system to model congenital HCMV infection.
    · The mouse CMV system by Zhou et al can be used for drug screening.

  • 加载中
    1. Carraro, M., Almishaal, A., Hillas, E., Firpo, M., Park, A., Harrison, R.V., 2017. Cytomegalovirus (CMV) infection causes degeneration of cochlear vasculature and hearing loss in a mouse model. J Assoc Res Otolaryngol 18, 263–273.

    2. Crough, T., Khanna, R., 2009. Immunobiology of human cytomegalovirus: from bench to bedside. Clin. Microbiol. Rev. 22, 76–98 (Table of Contents).

    3. de Juan Gallach, A., Alemany Albert, M., Marco Hernández, A.V., Boronat González, N., Cernada Badía, M., Tomás Vila, M., 2020. Neurological sequelae in patients with congenital cytomegalovirus. An. Pediatr. 93, 111–117 (In Spanish).

    4. Haller, T.J., Price, M.S., Lindsay, S.R., Hillas, E., Seipp, M., Firpo, M.A., Park, A.H., 2020. Effects of ganciclovir treatment in a murine model of cytomegalovirus-induced hearing loss. Laryngoscope 130, 1064–1069.

    5. Ikuta, K., Ogawa, H., Hashimoto, H., Okano, W., Tani, A., Sato, E., Kosugi, I., Kobayashi, T., Omori, K., Suzutani, T., 2015. Restricted infection of murine cytomegalovirus (MCMV) in neonatal mice with MCMV-induced sensorineural hearing loss. J. Clin. Virol. 69, 138–145.

    6. Moulden, J., Sung, C.Y.W., Brizic, I., Jonjic, S., Britt, W., 2021. Murine models of central nervous system disease following congenital human cytomegalovirus infections. Pathogens 10, 1062.

    7. Riga, M., Korres, G., Chouridis, P., Naxakis, S., Danielides, V., 2018. Congenital cytomegalovirus infection inducing non-congenital sensorineural hearing loss during childhood; a systematic review. Int. J. Pediatr. Otorhinolaryngol. 115, 156–164.

    8. Slavuljica, I., Kvestak, D., Huszthy, P.C., Kosmac, K., Britt, W.J., Jonjic, S., 2015. Immunobiology of congenital cytomegalovirus infection of the central nervous system-the murine cytomegalovirus model. Cell. Mol. Immunol. 12, 180–191.

    9. Tsutsui, Y., Kosugi, I., Kawasaki, H., Arai, Y., Han, G.P., Li, L., Kaneta, M., 2008. Roles of neural stem progenitor cells in cytomegalovirus infection of the brain in mouse models. Pathol. Int. 58, 257–267.

    10. Woolf, N.K., Jaquish, D.V., Koehrn, F.J., 2007. Transplacental murine cytomegalovirus infection in the brain of SCID mice. Virol. J. 4, 26.

    11. Zhou, Y.P., Mei, M.J., Wang, X.Z., Huang, S.N., Chen, L., Zhang, M., Li, X.Y., Qin, H.B., Dong, X., Cheng, S., Wen, L., Yang, B., An, X.F., He, A.D., Zhang, B., Zeng, W.B., Li, X.J., Lu, Y., Li, H.C., Li, H., Zou, W.G., Redwood, A.J., Rayner, S., Cheng, H., Mcvoy, M.A., Tang, Q., Britt, W.J., Zhou, X., Jiang, X., Luo, M.H., 2022. A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. JCI Insight 7, e152551.

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    Congenital cytomegalovirus infection and advances in murine models of neuropathogenesis

      Corresponding author: Qiyi Tang, qiyi.tang@howard.edu
    • Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA

    Abstract: Highlights
    · Congenital human cytomegalovirus (CMV) infection causes severe neuropathogenesis.
    · Murine CMV failed to break through the placental barrier to transmit to fetus.
    · Zhou et al. established a novel mouse system to model congenital HCMV infection.
    · The mouse CMV system by Zhou et al can be used for drug screening.

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