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. doi: 10.1016/j.virs.2022.04.014
Citation: Yue Lu, Ping He, Yuxuan Zhang, Yongwen Ren, Leiliang Zhang. The emerging roles of retromer and sorting nexins in the life cycle of viruses [J].VIROLOGICA SINICA, 2022, 37(3) : 321-330.


  • 通讯作者: 张磊亮,
  • 收稿日期: 2021-12-28
    录用日期: 2022-04-12
  • 逆转录复合物和分选连接蛋白(SNX)将货物从内体运输到跨高尔基网络或质膜,最近的研究揭示了逆转录复合物和SNX在病毒生命周期中的作用,包括冠状病毒科、黄病毒科和逆转录病毒科。逆转录复合物/SNX的关键成分,如Vps35、Vps26、SNX5和SNX27,可以影响病毒生命周期的多个步骤,包括促进病毒进入细胞、参与病毒复制和促进病毒粒子的组装。在这里,我们对逆转录复合物/SNX与病毒之间的相互作用进行了全面更新的回顾,这将为控制病毒感染提供机制见解。

The emerging roles of retromer and sorting nexins in the life cycle of viruses

  • Corresponding author: Leiliang Zhang,
  • Received Date: 28 December 2021
    Accepted Date: 12 April 2022
  • Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.

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    The emerging roles of retromer and sorting nexins in the life cycle of viruses

      Corresponding author: Leiliang Zhang,
    • a Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China;

    Abstract: Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.

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