. doi: 10.1016/j.virs.2022.10.002
Citation: Cheng Zhang, Zhong-Yi Wang, Huan Cui, Li-Gong Chen, Chun-Mao Zhang, Zhao-Liang Chen, Shi-Shan Dong, Kui Zhao, Ying-Ying Fu, Ju-Xiang Liu, Zhen-Dong Guo. Emergence of H5N8 avian influenza virus in domestic geese in a wild bird habitat, Yishui Lake, north central China .VIROLOGICA SINICA, 2023, 38(1) : 157-161.  http://dx.doi.org/10.1016/j.virs.2022.10.002

中国中北部易水湖野鸟栖息地家鹅中出现H5N8禽流感病毒

  • 禽流感病毒以其跨物种传播和大流行潜力而广为人知。近年来,2.3.4.4分支的H5N8亚型禽流感病毒在世界各地广泛传播,给家禽养殖业和人类健康带来了风险和威胁。在这项研究中,于2021年从一只家鹅身上分离到了一株H5N8亚型禽流感病毒(A/goose/Hebei/HG12/2021)。遗传进化分析显示,HG12毒株的HA基因来自2.3.4.4b分支,HG12毒株的八个内部基因均与俄罗斯人源H5N8亚型禽流感病毒有99.2%-99.8%的同源性,这表明野鸟在毒株传播中发挥了重要作用。HG12毒株能与α-2,3-连接的唾液酸(SA)受体结合。HG12毒株在A549细胞中的复制能力优于在MDCK细胞中的复制能力。HG12毒株对小鼠致病力很强,可在豚鼠间进行直接接触传播。这些结果强调了对家禽和野鸟中H5N8流感病毒进行持续监测和预警的必要性。

Emergence of H5N8 avian influenza virus in domestic geese in a wild bird habitat, Yishui Lake, north central China

  • Highlights
    1. H5N8 viruses emerged in the wild bird habitat at Yishui Lake.
    2. The homology between HG12 and a Russian human strain was over 99%.
    3. HG12 can be transmitted through direct contact between guinea pigs.

  • 加载中
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    Emergence of H5N8 avian influenza virus in domestic geese in a wild bird habitat, Yishui Lake, north central China

      Corresponding author: Ju-Xiang Liu, ljx0315@126.com
      Corresponding author: Zhen-Dong Guo, guozd@foxmail.com
    • a. Changchun Veterinary Research Institute at Chinese Academy of Agriculture Sciences, Changchun 130122, China;
    • b. Beijing Institute of Biotechnology, Beijing 100071, China;
    • c. College of Veterinary Medicine at Jilin University, Changchun 130062, China;
    • d. College of Veterinary Medicine at Hebei Agricultural University, Baoding 071000, China

    Abstract: Highlights
    1. H5N8 viruses emerged in the wild bird habitat at Yishui Lake.
    2. The homology between HG12 and a Russian human strain was over 99%.
    3. HG12 can be transmitted through direct contact between guinea pigs.

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