. doi: 10.1016/j.virs.2022.10.008
Citation: Mengying Liang, Wanbo Tai, Yunyun Wang, Yulong Dai, Yanfeng Yao, Juan Min, Yiwu Zhou, Liang Liu, Chao Shan, Han Xia, Zhiming Yuan. SARS-CoV-2 infection induces testicular injury in Rhesus macaque .VIROLOGICA SINICA, 2022, 37(6) : 934-937.  http://dx.doi.org/10.1016/j.virs.2022.10.008

SARS-CoV-2感染可导致恒河猴睾丸损伤

  • 本研究利用前期建立SARS-CoV-2恒河猴感染模型中所获得的血液和雄性生殖系统样本,初步开展了SARS-CoV-2感染对恒河猴生殖系统的病理损伤和功能影响的研究。结果表明,SARS-CoV-2感染可导致恒河猴睾丸不同程度的病理损伤,而这一损伤的形成可能与感染所引起的炎症反应和性激素波动有关,而非病毒在靶器官直接感染所导致。这一发现有利于今后进一步全面评估SARS-CoV-2感染所导致的风险。

SARS-CoV-2 infection induces testicular injury in Rhesus macaque

  • Highlights
    1 The infection of SARS-CoV-2 lead to varying degrees of testicular pathological damage.
    2 The NP antigen of SARS-CoV-2 was not found in male reproductive system of rhesus macaque.
    3 Infection-associated inflammatory insult and sex hormone fluctuations may account for the testicular pathophysiology.

  • 加载中
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  • 10.1016j.virs.2022.10.008-ESM.doc

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    SARS-CoV-2 infection induces testicular injury in Rhesus macaque

      Corresponding author: Han Xia, hanxia@wh.iov.cn
      Corresponding author: Zhiming Yuan, yzm@wh.iov.cn
    • a Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430061, China;

    Abstract: Highlights
    1 The infection of SARS-CoV-2 lead to varying degrees of testicular pathological damage.
    2 The NP antigen of SARS-CoV-2 was not found in male reproductive system of rhesus macaque.
    3 Infection-associated inflammatory insult and sex hormone fluctuations may account for the testicular pathophysiology.

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