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Volume 38 Issue 2
April 2023

    . doi: 10.1016/j.virs.2022.12.008
    Citation: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji. Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees .VIROLOGICA SINICA, 2023, 38(2) : 233-243.  http://dx.doi.org/10.1016/j.virs.2022.12.008
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    奥秘克柔突破感染诱导的特异性记忆免疫高于第三针加强免疫

    • a. 检验科, 广州医科大学附属第二医院, 广州, 510260, 中国;

    • b. 国家呼吸疾病重点实验室, 粤港澳呼吸系统传染病联合实验室, 广州生物医药与健康研究院, 广州, 510535, 中国;

    • c. 检验科, 东莞市第九人民医院, 东莞, 523016, 中国;

    • d. 国家呼吸疾病重点实验, 广州呼吸健康研究院, 广州医科大学附属第一医院, 525000, 中国;

    • e. 检验科, 茂名市人民医院, 525000, 中国;

    • f. 病理实验室, 病理科, 阿巴拉契亚州立大, 12350, 巴基斯坦;

    • g. 院感科, 广州医科大学附属第二医院, 广州, 510260, 中国;

    • h. 体检科, 广州医科大学附属第二医院, 广州, 510260, 中国;

    • i. 检验科, 广州医科大学附属第二医院, 广州, 510140, 中国;

    • j. 移植科, 广州医科大学附属第二医院, 广州, 510260, 中国;

    • k. 广州市传染性疾病临床快速诊断与预警重点实验室, 金域检验学院, 广州医科大学, 511436, 中国

    • 同源性加强免疫、异源性加强免疫、和奥秘克柔病毒株突破感染均可有效地诱导机体产生奥秘克柔病毒特异性抗体。但，有关奥秘克柔病毒株特异性记忆B细胞和T细胞免疫仍未知。在此，对比分析表明Ad5-nCoV加强免疫诱导的原始病毒株、德尔塔和奥秘克柔病毒株特异性抗体和T细胞免疫水平和奥秘克柔病毒株突破感染相当，但高于同源性灭活疫苗加强免疫。然而，奥秘克柔病毒株特异性记忆B细胞免疫在奥秘克柔病毒株突破感染患者体内水平最高，依次为Ad5-nCoV加强免疫和同源性灭活疫苗加强免疫。与同源性加强免疫相比，奥秘克柔病毒株突破感染和Ad5-nCoV加强免疫诱导的传统性记忆B细胞和激活性记忆B细胞水平较高，而初始记忆B细胞和非典型记忆B细胞水平较低。总之，奥秘克柔病毒株突破感染诱导机体产生的奥秘克柔病毒株特异性记忆性B细胞和T细胞免疫水平明显高于同源性加强免疫和异源性加强免疫。

    Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

    • a. Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;

    • b. State Key Laboratories of Respiratory Diseases, Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510535, China;

    • c. Clinical Laboratory Medicine Department, Dongguan Ninth People's Hospital, Dongguan, 523016, China;

    • d. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China;

    • e. Clinical Laboratory Medicine Department, Maoming People's Hospital, Maoming, 525000, China;

    • f. Laboratory of Pathology, Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir Pakistan 12350, Pakistan;

    • g. Hospital Infection-Control Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;

    • h. Medical Examination Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;

    • i. Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510140, China;

    • j. Kidney Transplant Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;

    • k. Department of Organ Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, 510630, China;

    • l. Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, China

    • Homologous booster, heterologous booster, and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against Omicron variants. Questions concerning about memory B cells (MBCs) and T cells immunity against Omicron variants, features of long-term immunity, after booster and OBI, needs to be explored. Here, comparative analysis demonstrate antibody and T cell immunity against ancestral strain, Delta and Omicron variants in Omicron breakthrough infected patients (OBIPs) are comparable to that in Ad5-nCoV boosted healthy volunteers (HVs), higher than that in inactivated vaccine (InV) boosted HVs. However, memory B cells (MBCs) immunity against Omicron variants was highest in OBIPs, followed by Ad5-nCoV boosted and InV boosted HVs. OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs, and lower naïve MBCs and atypical MBCs relative to both vaccine boosted HVs. Collectively, these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.
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      Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

        Corresponding author: Zheng Chen, docchenzheng@163.com
        Corresponding author: Yuemei Liang, 784604898@qq.com
        Corresponding author: Pingchao Li, li_pingchao@gibh.ac.cn
        Corresponding author: Lei Zhang, 517728181@qq.com
        Corresponding author: Tianxing Ji, jitianxing7021@163.com
      • a. Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;
      • b. State Key Laboratories of Respiratory Diseases, Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510535, China;
      • c. Clinical Laboratory Medicine Department, Dongguan Ninth People's Hospital, Dongguan, 523016, China;
      • d. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China;
      • e. Clinical Laboratory Medicine Department, Maoming People's Hospital, Maoming, 525000, China;
      • f. Laboratory of Pathology, Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir Pakistan 12350, Pakistan;
      • g. Hospital Infection-Control Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;
      • h. Medical Examination Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;
      • i. Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510140, China;
      • j. Kidney Transplant Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China;
      • k. Department of Organ Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, 510630, China;
      • l. Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511436, China
      • Received Date: 16 September 2022
      • Accepted Date: 30 December 2022

      Abstract: Homologous booster, heterologous booster, and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against Omicron variants. Questions concerning about memory B cells (MBCs) and T cells immunity against Omicron variants, features of long-term immunity, after booster and OBI, needs to be explored. Here, comparative analysis demonstrate antibody and T cell immunity against ancestral strain, Delta and Omicron variants in Omicron breakthrough infected patients (OBIPs) are comparable to that in Ad5-nCoV boosted healthy volunteers (HVs), higher than that in inactivated vaccine (InV) boosted HVs. However, memory B cells (MBCs) immunity against Omicron variants was highest in OBIPs, followed by Ad5-nCoV boosted and InV boosted HVs. OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs, and lower naïve MBCs and atypical MBCs relative to both vaccine boosted HVs. Collectively, these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.

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