. doi: 10.1016/j.virs.2023.01.004
Citation: Lidan Hou, Zengna Chi, Yawen Zhang, Qi Xue, Tianshu Zhai, Shuang Chang, Jia Wang, Peng Zhao. Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei, China .VIROLOGICA SINICA, 2023, 38(2) : 317-320.  http://dx.doi.org/10.1016/j.virs.2023.01.004

从中国河北省父母代鸡群临床病例中鉴定到E8b血清型禽腺病毒和禽戊型肝炎病毒的共感染

  • 本研究首次报道了从发生肝脏损伤的中国河北省父母代鸡群病例中鉴定到血清E 8b型禽腺病毒(FAdV-E 8b)和禽戊型感染病毒(aHEV)的共感染,并对FAdV-8b和aHEV主要基因进行了测序分析。结合临床发病表现,推测FAdV-8b和aHEV在体内的共感染可增强对鸡的致病性。本研究提示FAdV-8b和aHEV共感染的危害不容忽视,要强化对FAdV和aHEV感染的持续监测。

Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei, China

  • Highlights
    1. Co-infection of fowl adenovirus (FAdV) and avian hepatitis E virus (aHEV) was observed in layer breeders.
    2. All three main genes of FAdV isolate share high homology with the E-8b type.
    3. ORF2 from aHEV showed homology with VaHEV strain from Hy-line LCFs in China.

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    7. Su, Q., Li, Y., Zhang, Y., Zhang, Z., Meng, F., Cui, Z., Chang, S., Zhao, P., 2018. Characterization of the novel genotype avian hepatitis E viruses from outbreaks of hepatic rupture haemorrhage syndrome in different geographical regions of china. Transbound. Emerg. Dis. 65, 2017-2026.

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    10. Sun, Z.F., Larsen, C.T., Dunlop, A., Huang, F.F., Pierson, F.W., Toth, T.E., Meng, X.J., 2004. Genetic identification of avian hepatitis E virus (HEV) from healthy chicken flocks and characterization of the capsid gene of 14 avian HEV isolates from chickens with hepatitis-splenomegaly syndrome in different geographical regions of the United States. J. Gen. Virol. 85, 693-700.

    11. Yang, S., Wang, L., Sun, S., 2016. Natural infection with avian hepatitis E virus and Marek's disease virus in brown layer chickens in China. Avian. Dis. 60, 698-704.

    12. Ye, J., Liang, G., Zhang, J., Wang, W., Song, N., Wang, P., Zheng, W., Xie, Q., Shao, H., Wan, Z., Wang, C., Chen, H., Gao, W., Qin, A., 2016. Outbreaks of serotype 4 fowl adenovirus with novel genotype, China. Emerg. Microbes. Infect. 5, e50.

    13. Yu, G., Lin, Y., Dou, Y., Tang, Y., Diao, Y., 2019. Prevalence of fowl adenovirus serotype 4 and co-infection by immunosuppressive viruses in fowl with hydropericardium hepatitis syndrome in Shandong province, China. Viruses, 11, 517.

    14. Zhang, Y., Zhao, H., Chi, Z., Cui, Z., Chang, S., Wang, Y., Zhao, P., 2022. Isolation, identification and genome analysis of an avian hepatitis E virus from white-feathered broilers in China. Poult. Sci. 101, 101633.

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    Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei, China

      Corresponding author: Jia Wang, w2000j1980@hotmail.com
      Corresponding author: Peng Zhao, zhaopeng@sdau.edu.cn
    • a. China Institute of Veterinary Drug Control, Beijing, 100081, China;
    • b. College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an City, 271018, China

    Abstract: Highlights
    1. Co-infection of fowl adenovirus (FAdV) and avian hepatitis E virus (aHEV) was observed in layer breeders.
    2. All three main genes of FAdV isolate share high homology with the E-8b type.
    3. ORF2 from aHEV showed homology with VaHEV strain from Hy-line LCFs in China.

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