Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China

Shuo Zhang; Yu Leng; Fa-Xue Zhang; Bo-Kang Fu; Bing-Zheng Wu; Jia-Hao Chen; Ning Cui; Ning Zhao; Wei Liu; Hao Li

doi:10.1016/j.virs.2024.03.006

June 2024

Shuo Zhang, Yu Leng, Fa-Xue Zhang, Bo-Kang Fu, Bing-Zheng Wu, Jia-Hao Chen, Ning Cui, Ning Zhao, Wei Liu and Hao Li. Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China[J]. Virologica Sinica, 2024, 39(3): 513-515. doi: 10.1016/j.virs.2024.03.006

Citation: Shuo Zhang, Yu Leng, Fa-Xue Zhang, Bo-Kang Fu, Bing-Zheng Wu, Jia-Hao Chen, Ning Cui, Ning Zhao, Wei Liu, Hao Li. Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China .VIROLOGICA SINICA, 2024, 39(3) : 513-515. http://dx.doi.org/10.1016/j.virs.2024.03.006

由猫接触引起的发热伴血小板减少综合征病毒感染：中国北京一例病例报告

张烁 ^a,b ,
冷昱 ^b ,
张发雪 ^c ,
付伯康 ^b,d ,
吴炳征 ^b ,
陈家浩 ^b ,
崔宁 ^e ,
赵宁 ^a,, ,
刘玮 ^a,b,d,, ,
黎浩 ^b,c,,

cstr: 32224.14.j.virs.2024.03.006

a. 西南林业大学;
b. 病原微生物生物安全全国重点实验室;
c. 武汉大学公共卫生学院;
d. 安徽医科大学第一附属医院;
e. 信阳154医院

通讯作者： 赵宁, lijiangzhaon@swfu.edu.cn; 刘玮, liuwei@bmi.ac.cn; 黎浩, lihao_1986@126.com
收稿日期： 2023-12-24
录用日期： 2024-03-14

摘要

发热伴血小板减少综合征是一种高病死率的蜱传病毒性出血热疾病，易发生在居住于农村、山区或者具有蜱虫暴露高风险的人群中。本研究报告了1例居住在北京市城乡结合区、无蜱虫叮咬史的发热伴血小板减少综合征确诊病例。流行病学调查发现该患者曾被可能感染发热伴血小板减少综合征病毒的猫挠伤。序列分析显示患者和猫携带的病毒S片段相似性为100%。进一步现场调查发现病人居住地周围的游离蜱和山羊寄生蜱均存在发热伴血小板减少综合征病毒感染。系统发育分析发现蜱虫携带病毒存在两种基因型，其中一种与患者、猫携带病毒相似。这些研究发现不仅提示北京市城乡结合地区可能存在多种发热伴血小板减少综合征病毒基因型的流行，也警示应当注意经猫传人的发热伴血小板减少综合征潜在传播途径。
- 发热伴血小板减少综合征
- , 蜱媒传染病
- , 长角血蜱
- , 猫
- , 北京

Severe fever with thrombocytopenia syndrome virus infection attributed to cat contact: A case report in Beijing, China

Shuo Zhang ^a,b ,
Yu Leng ^b ,
Fa-Xue Zhang ^c ,
Bo-Kang Fu ^b,d ,
Bing-Zheng Wu ^b ,
Jia-Hao Chen ^b ,
Ning Cui ^e ,
Ning Zhao ^a,, ,
Wei Liu ^a,b,d,, ,
Hao Li ^b,c,,

a. College of Life Sciences, Southwest Forestry University, Kunming, 650224, China;
b. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases, Beijing, 100071, China;
c. School of Public Health, Wuhan University, Wuhan, 430071, China;
d. The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China;
e. Xinyang 154 Hospital, Xinyang, 464000, China

Corresponding author: Ning Zhao, lijiangzhaon@swfu.edu.cn Wei Liu, liuwei@bmi.ac.cn Hao Li, lihao_1986@126.com
Received Date: 24 December 2023
Accepted Date: 14 March 2024

Abstract

Highlights1. SFTSV is detected in host-seeking ticks in rural-urban fringe areas in Beijing.2. SFTSV RNA, IgM, and neutralizing antibodies are detected in stray cats in Beijing.3. Multiple SFTSV genotypes naturally circulate within ticks in Beijing's urban zones.

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Electronic Supplementary Material

10.1016j.virs.2024.03.006-ESM.docx