Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023

Xuanxuan Li; Zefeng Dong; Jiaming Li; Chuanran Dou; Deyu Tian; Zhenghai Ma; Wenjun Liu; George F. Gao; Yuhai Bi

doi:10.1016/j.virs.2024.05.003

June 2024

Xuanxuan Li, Zefeng Dong, Jiaming Li, Chuanran Dou, Deyu Tian, Zhenghai Ma, Wenjun Liu, George F. Gao and Yuhai Bi. Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023[J]. Virologica Sinica, 2024, 39(3): 520-523. doi: 10.1016/j.virs.2024.05.003

Citation: Xuanxuan Li, Zefeng Dong, Jiaming Li, Chuanran Dou, Deyu Tian, Zhenghai Ma, Wenjun Liu, George F. Gao, Yuhai Bi. Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023 .VIROLOGICA SINICA, 2024, 39(3) : 520-523. http://dx.doi.org/10.1016/j.virs.2024.05.003

2023年初中国H1N1流感病毒的遗传特征

李萱萱 ^a,b ,
董泽丰 ^c ,
李佳明 ^b ,
窦川然 ^d ,
田德雨 ^b ,
马正海 ^a ,
刘文军 ^b,e ,
高福 ^b,e,f ,
毕玉海 ^b,e,,

cstr: 32224.14.j.virs.2024.05.003

a. 新疆大学生命科学学院;
b. 中国科学院微生物研究所病原微生物与免疫学重点实验室, 中国科学院流感研究与预警中心, 中国科学院新发传染病卓越中心;
c. 苏州市疾病预防控制中心;
d. 拉斐特学院, 美国;
e. 中国科学院大学;
f. . 浙江大学陈廷骅大健康学院

通讯作者： 毕玉海, beeyh@im.ac.cn
收稿日期： 2023-10-25
录用日期： 2024-05-09

摘要

为探究新冠肺炎防控政策优化后H1N1流感病毒的遗传特征，本研究对我国2023年第一季度湖南省和江苏省采集的48株H1N1流感病毒进行了遗传进化分析。通过对HA基因的系统发育树和抗原位点分析，我们发现了新冠肺炎防控政策优化后流行的H1N1病毒与当时使用或下一年度推荐的疫苗株之间存在不匹配的现象，提示急需一个更加精确的疫苗更新计划。
- 流感病毒
- , H1N1
- , 遗传演化

Genetic characteristics of H1N1 influenza virus outbreak in China in early 2023

Xuanxuan Li ^a,b ,
Zefeng Dong ^c ,
Jiaming Li ^b ,
Chuanran Dou ^d ,
Deyu Tian ^b ,
Zhenghai Ma ^a ,
Wenjun Liu ^b,e ,
George F. Gao ^b,e,f ,
Yuhai Bi ^b,e,,

a. College of Life Science and Technology, Xinjiang University, Urumchi, 830046, China;
b. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China;
c. Suzhou Center for Disease Control and Prevention, Suzhou, 215004, China;
d. Lafayette College, Easton, PA 18042, USA;
e. University of Chinese Academy of Sciences, Beijing, 100049, China;
f. D. H. Chen School of Universal Health, Zhejiang University, Hangzhou 310058, China

Corresponding author: Yuhai Bi, beeyh@im.ac.cn
Received Date: 25 October 2023
Accepted Date: 09 May 2024

Abstract

Highlights
1. H1N1 strains were collected from Hunan and Jiangsu provinces in early 2023 following the optimized COVID-19 strategy.
2. Phylogenic analysis revealed that the epidemic H1N1 viruses fell into different HA clades compared to vaccine strains.
3. Mutations on HA antigenic sites suggest antigenic drift in the epidemic H1N1 viruses versus vaccine strains.
4. A potential mismatch was found between recommended vaccine strains and the epidemic H1N1 viruses.
5. The expeditious, precise, and personalized vaccine update program for influenza virus may need to be put on the agenda.

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Electronic Supplementary Material

10.1016j.virs.2024.05.003-ESM.docx