Jinzhu Feng, Zeyu Pu, Rong Li, Yuzhuang Li, Xuewen Qin, Hui Zhang and Yiwen Zhang. Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection[J]. Virologica Sinica, 2024, 39(4): 699-701. doi: 10.1016/j.virs.2024.06.002
Citation: Jinzhu Feng, Zeyu Pu, Rong Li, Yuzhuang Li, Xuewen Qin, Hui Zhang, Yiwen Zhang. Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection .VIROLOGICA SINICA, 2024, 39(4) : 699-701.  http://dx.doi.org/10.1016/j.virs.2024.06.002

循环滤泡辅助T细胞(cTfh)水平与COVID-19再感染风险相关

cstr: 32224.14.j.virs.2024.06.002
  • 由于新冠病毒的持续突变,既往感染中诱导产生的特异性中和抗体在机体暴露于新流行株时的保护力大大削弱,其效价难以用于判断再次感染的发生风险。进一步对机体遭遇再次感染时的免疫动态进行研究,识别潜在的免疫学指标对于我们加深理解再次感染的发生具有重要意义。基于此,在本项研究中,我们针对22年底BA.5感染潮后处于康复期的人群进行志愿者招募和多次回溯,在23年5月XBB感染潮出现后建立了一个独特难得的封闭环境内感染者队列。通过血清学检测方法包括酶联免疫吸附测定(ELISA)和假病毒中和实验(PVNT),我们确定队列中有48%的志愿者在两轮感染潮中均感染(再次感染组),而其余52%则仅在第一轮感染潮中感染(单次感染组)。我们发现单次感染组在感染症状出现后一个月中针对BA.5的中和抗体(nAb)水平显著高于再次感染组。此外,我们使用酶联免疫斑点(ELISpot)和细胞内细胞因子染色(ICCS)对单次感染和再次感染组中的T细胞亚型进行了全面分析。深入研究CD4+ T细胞亚型时,我们发现单次感染组在感染症状出现后一个月内表现出更高比例的循环滤泡辅助T细胞(cTfh)。进一步分析揭示,nAb滴度的增加与cTfh细胞的比例显著相关,突出了cTfh细胞水平与体液免疫应答强度之间的潜在关联。综上所述,我们对不同的COVID-19易感人群进行了回顾性分析,发现免疫早期拥有较高中和抗体水平且存在较高比例循环滤泡辅助T细胞(cTfh)的人群,其再次感染SARS-CoV-2的风险较低。这凸显了cTfh在下一代疫苗中的重要作用,为预防新冠再次感染提供了关键的指导策略。

Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection

  • Highlights1. Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.2. The correlation between cTfh cells and neutralizing antibodies enhances protection against SARS-CoV-2.3. cTfh cell responses are positively associated with a decreased risk of SARS-CoV-2 reinfection.

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    10. Zhang J, Wu Q, Liu Z, Wang Q, Wu J, Hu Y, Bai T, Xie T, Huang M, Wu T, Peng D, Huang W, Jin K, Niu L, Guo W, Luo D, Lei D, Wu Z, Li G, Huang R, Lin Y, Xie X, He S, Deng Y, Liu J, Li W, Lu Z, Chen H, Zeng T, Luo Q, Li YP, Wang Y, Liu W, Qu X, 2021. Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals. Nat Microbiol 6, 51-58.

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    Correlation between circulating T follicular helper cell levels after infection and a decreased risk of COVID-19 re-infection

      Corresponding author: Hui Zhang, zhangh92@mail.sysu.edu.cn
      Corresponding author: Yiwen Zhang, zhangyw57@mail.sysu.edu.cn
    • Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China

    Abstract: Highlights1. Our study conducted a retrospective analysis of individuals with differing susceptibilities to COVID-19.2. The correlation between cTfh cells and neutralizing antibodies enhances protection against SARS-CoV-2.3. cTfh cell responses are positively associated with a decreased risk of SARS-CoV-2 reinfection.

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