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Volume 39 Issue 4
August 2024

    Jie-Mei Yu, Ze-Yin Liang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Yu-Jun Dong and Jin-Sheng He. Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual[J]. Virologica Sinica, 2024, 39(4): 705-707. doi: 10.1016/j.virs.2024.06.006
    Citation: Jie-Mei Yu, Ze-Yin Liang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Yu-Jun Dong, Jin-Sheng He. Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual .VIROLOGICA SINICA, 2024, 39(4) : 705-707.  http://dx.doi.org/10.1016/j.virs.2024.06.006
    shu

    免疫抑制病人中AAV2与AdV18或HSV-1的同时存在可能与严重舌乳头瘤状赘生物相关

    cstr: 32224.14.j.virs.2024.06.006

    • a. 北京交通大学;

    • b. 北京大学第一医院

    • 本研究对一名接受造血干细胞移植且长有严重舌乳头瘤状赘生物的患者粪便和赘生物组织样本进行了病毒宏基因组学分析。结果显示，两种样本中均含有大量的腺相关病毒2型（AAV2）序列，同时，粪便和组织样本中分别含有大量的可作为AAV2潜在辅助病毒的腺病毒血清型18 （AdV18）和疱疹病毒1型（HSV-1）。虽未明确确定直接因果关系，但这些病毒的同时存在提示其与免疫抑制病人严重的舌乳头瘤状赘生物发展之间可能存在联系。值得注意的是，本研究获得了一株AdV18的完整基因组序列，这也是迄今为止报道的AdV18的第二条全基因组序列。与以往序列相比，本研究中报道序列的聚合酶区存在三个氨基酸替换，六面体蛋白区有一个氨基酸替换，但系统发育分析揭示本研究中AdV18的聚合酶和六面体区域与先前报道的AdV18序列紧密关联。本研究数据为探讨腺病毒的遗传变异性、起源和致病性等提供了重要数据，同时强调了对HSCT患者进行全面的病原体筛查在阐明严重舌乳头瘤状赘生物病因学中具有重要作用。

    Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

    • a. College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044, China;

    • b. Department of Hematology, Peking University First Hospital, Beijing, 100034, China

    • Highlights
      1. Viral metagenomics analysis was conducted on samples from an HSCT recipient experiencing severe lingual papillomatosis.
      2. Coexistence of AAV2 with AdV18 in fecal and HSV-1 in tissue samples was detected.
      3. A second complete genome of AdV18 was obtained in this study and is available in public databases.
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      1. Armstrong, A. E., Rossoff, J., Hollemon, D., Hong, D. K., Muller, W. J., & Chaudhury, S., 2019. Cell-free DNA next-generation sequencing successfully detects infectious pathogens in pediatric oncology and hematopoietic stem cell transplant patients at risk for invasive fungal disease. Pediatr. Blood Cancer 66, e27734.

      2. Gates, S., Andreani, J., Dewar, R., Smith, D.B., Templeton, K., Child, H.T., Breuer, J., Golubchik, T., Bassano, I., Wade, M.J. et al., 2023. Postpandemic rebound of adeno-associated virus type 2 (AVV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom. J. Med. Virol. 95, e28921.

      3. Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., Tong, L., Smollett, K., Manali, M., Allan, J. et al., 2023. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature, 617, 555-563.

      4. Hoeben, R.C., Uil, T.G., 2013. Adenovirus DNA replication. Cold Spring Harb. Perspect. Biol. 5, a013003.

      5. Huebner, R.J., Rowe, W.P., Lane, W.T., 1962. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc. Natl. Acad. Sci. U S A. 48, 2051-2058.

      6. La Bella, T., Imbeaud, S., Peneau, C., Mami, I., Datta, S., Bayard, Q., Caruso, S., Hirsch, T.Z., Calderaro J., Morcrette G. et al., 2020. Adeno-associated virus in the liver: natural history and consequences in tumour development. Gut. 69, 737-747.

      7. Liu, H.T., Naismith, J.H., Hay, R.T., 2000. Identification of conserved residues contributing to the activities of adenovirus DNA polymerase. J. Virol. 74, 11681-11689.

      8. Meier, A.F., Fraefel, C., Seyffert, M., 2020. The interplay between adeno-associated virus and its helper viruses. Viruses 12, 662.

      9. Moyo, S.J., Hanevik, K., Blomberg, B., Kommedal, O., Nordbo, S.A., Maselle, S., Langeland N., 2014. Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study. BMC Infect. Dis. 14, 666.

      10. Peng, J.M., Du, B., Qin, H.Y., Wang, Q., Shi, Y., 2021. Metagenomic next-generation sequencing for the diagnosis of suspected pneumonia in immunocompromised patients. J. Infect. 82, 22-27.

      11. Qu, Y.H., Ding, W.J., Liu, S., Wang, X.J., Wang, P.F., Liu, H.Y., Xia, H., Chen, Y., Jiang, H., 2022. Metagenomic next-generation sequencing vs. Traditional pathogen detection in the diagnosis of infection after allogeneic hematopoietic stem cell transplantation in children. Front. Microbiol. 13, 868160.

      12. Sahin, U., Toprak, S.K., Atilla, P.A., Atilla, E., Demirer, T., 2016. An overview of infectious complications after allogeneic hematopoietic stem cell transplantation. J. Infect. Chemother. 22, 505-514.

      13. Schuler, B.A., Nelson, E.T., Koziura, M., Cogan, J.D., Hamid, R., Phillips, J.A., 2022. Lessons learned: Next-generation sequencing applied to undiagnosed genetic diseases. J. Clin. Invest. 132, e154942.

      14. Wang, D., Tai, P.W.L., Gao, G.P., 2019. Adeno-associated virus vector as a platform for gene therapy delivery. Nat. Rev. Drug Discov. 18, 358-378.

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      Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

        Corresponding author: Yu-Jun Dong, dongy@bjmu.edu.cn
        Corresponding author: Jin-Sheng He, jshhe@bjtu.edu.cn
      • a. College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044, China;
      • b. Department of Hematology, Peking University First Hospital, Beijing, 100034, China
      • Received Date: 16 October 2023
      • Accepted Date: 19 June 2024

      Abstract: Highlights
      1. Viral metagenomics analysis was conducted on samples from an HSCT recipient experiencing severe lingual papillomatosis.
      2. Coexistence of AAV2 with AdV18 in fecal and HSV-1 in tissue samples was detected.
      3. A second complete genome of AdV18 was obtained in this study and is available in public databases.

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