The first discovery of severe fever with thrombocytopenia virus in the center of metropolitan Beijing, China

Fei Yuan; Lianglong Zhu; Di Tian; Mengyu Xia; Ming-hao Zheng; Qing Zhang; Tingyu Zhang; Xing Zhang; Aihua Zheng

doi:10.1016/j.virs.2024.11.002

December 2024

. doi: 10.1016/j.virs.2024.11.002

Citation: Fei Yuan, Lianglong Zhu, Di Tian, Mengyu Xia, Ming-hao Zheng, Qing Zhang, Tingyu Zhang, Xing Zhang, Aihua Zheng. The first discovery of severe fever with thrombocytopenia virus in the center of metropolitan Beijing, China .VIROLOGICA SINICA, 2024, 39(6) : 875-881. http://dx.doi.org/10.1016/j.virs.2024.11.002

在北京市中心城区首次发现发热伴血小板减少综合征病毒（SFTSV）

袁菲 ^a ,
朱良隆 ^a,b ,
田地 ^c ,
夏梦禹 ^a,b ,
郑明昊 ^d ,
张清 ^c ,
张婷玉 ^c ,
张星 ^a,e,, ,
郑爱华 ^a,b,,

cstr: 32224.14.j.virs.2024.11.002

a. 中国科学院动物研究所, 北京 100101;
b. 中国科学院大学生物互作卓越创新中心, 北京 100049;
c. 北京地坛医院, 北京 100069;
d. 中国人民大学附属中学, 北京 100872;
e. 中国科学院大学生命科学学院, 北京 100049

通讯作者： 张星, zhangxing@ucas.ac.cn; 郑爱华, zhengaihua@ioz.ac.cn
收稿日期： 2024-06-04
录用日期： 2024-11-05

摘要

发热伴血小板减少综合征病毒（SFTSV）是一种新发蜱传病毒，自2009年被发现以来，对中国农村地区的公共卫生造成了严重威胁。2021年，北京首例SFTSV感染病例出现在门头沟地区，随后城乡结合部的病例逐年增加。本研究对北京市中心城区（二环至五环）的蜱虫和刺猬的分布、种类及病毒携带情况进行了调查，发现北京城市公园内存在多样化的蜱虫群体，其中包括SFTSV的主要传播媒介—长角血蜱（Haemaphysalis longicornis）。在故宫附近的北海公园和陶然亭公园，还发现了孤雌生殖的长角血蜱，孤雌种群的长角血蜱已被报道在SFTSV的快速传播中发挥了重要作用。调查还显示，在北京市中心捕获的刺猬及其寄生蜱中，SFTSV的血清阳性率和RNA阳性率均较高。对从刺猬和蜱虫中扩增得到的SFTSV序列以及孤雌生殖长角血蜱的线粒体序列进行的系统进化分析表明，北京地区存在不同的SFTSV和长角血蜱谱系，这提示可能发生了多次入侵事件。这些研究结果揭示了SFTSV已经在北京市中心城区的刺猬和蜱虫中形成循环，需要引起高度重视并加强监测。
- 发热伴血小板减少综合征病毒
- , 刺猬
- , 长角血蜱
- , 中心城区
- , 北京

The first discovery of severe fever with thrombocytopenia virus in the center of metropolitan Beijing, China

Fei Yuan ^a ,
Lianglong Zhu ^a,b ,
Di Tian ^c ,
Mengyu Xia ^a,b ,
Ming-hao Zheng ^d ,
Qing Zhang ^c ,
Tingyu Zhang ^c ,
Xing Zhang ^a,e,, ,
Aihua Zheng ^a,b,,

a. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;
b. CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China;
c. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100069, China;
d. The High School Affiliated to Renmin University of China, Beijing 100872, China;
e. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Xing Zhang, zhangxing@ucas.ac.cn Aihua Zheng, zhengaihua@ioz.ac.cn
Received Date: 04 June 2024
Accepted Date: 05 November 2024

Abstract

Severe fever with thrombocytopenia virus (SFTSV), an emerging tick-borne bandavirus, poses a significant public health threat in rural China. Since 2021, an increase of local cases has been noted in the rural-urban fringe of Beijing. This study aimed to assess the formation of natural foci in urban areas by conducting a field survey of ticks and hedgehogs from the second to fifth ring roads of Beijing. Our survey revealed a diverse tick population in city parks, including the major SFTSV vector, Haemaphysalis longicornis. Parthenogenetic H. longicornis, known for its role in the rapid spread of SFTSV, was identified in key locations such as Beihai Park and Taoranting Park, near the Forbidden City. Notably, high SFTSV seroprevalence and RNA prevalence were found in hedgehogs and parasitic ticks in the center of Beijing. Phylogenetic analyses of SFTSV RNA and mitochondrial sequences of parthenogenetic H. longicornis ticks revealed the existence of diverse lineages of SFTSV and H. longicornis ticks within Beijing, suggesting multiple invasion events happened. These findings reveal the circulation of SFTSV in central Beijing, highlighting the need for urgent attention and enhanced surveillance measures.
- Severe fever with thrombocytopenia virus (SFTSV)
- , Hedgehog
- , Haemaphysalis longicornis
- , Urban
- , Beijing

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