XIONG Kai-Jun, HUANG Hua-Fang, JIN Wei-E, YAO Meng-Lin, ZENG Lin-Lan, HE Yong-Wen, HE Sheng-Song and WU Zhang-Qi. THE INFLUENCE OF SMALL DOSAGES OF INTERFERON ON VIRUSES ON DIFFERENT STAGES OF CHRONIC HEPATITIS B[J]. Virologica Sinica, 1986, 1(3).
Citation:
XIONG Kai-Jun, HUANG Hua-Fang, JIN Wei-E, YAO Meng-Lin, ZENG Lin-Lan, HE Yong-Wen, HE Sheng-Song, WU Zhang-Qi.
THE INFLUENCE OF SMALL DOSAGES OF INTERFERON ON VIRUSES ON DIFFERENT STAGES OF CHRONIC HEPATITIS B .VIROLOGICA SINICA, 1986, 1(3)
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不同疗程小剂量干扰素对慢性乙型肝炎病毒标志物的影响
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1.
同济医大协和医院传染病教研室
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2.
中国科学院武汉病毒研究所 武汉
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摘要
本文应用小剂量干扰素,从1个月至6个月不同疗程治疗97例HBsAg阳性伴HBeAg阳佳60例慢性乙型肝炎病人,以HBsAg、HBeAg、抗-HBe、HBcAg、DNAP和HBV-DNA 6项作为抗病毒指标,经1个月疗程97例,6项指标均无明显改善,经2个月疗程77例,只有DNAP阳性率下降和HBeAg阳性下降明显,经3个月疗程60例,5项病毒指标(除HBV-DNA外)均有统计学意义的下降,经6个月疗程42例,5项病毒指标阳性率稳定下降,下降缓慢的HBV-DNA(从73.24％下降为23.1％)和HBsAg(从100％下降为50％)也明显下降。这些病毒指标中以DNAP和HBeAg最敏感,次为HBcAg,再为HBV-DNA,最不敏感是HBsAg。本结果表明小剂量干扰素有抑制乙肝病毒复制怍用,长疗程(3个月以上)优于短程。
THE INFLUENCE OF SMALL DOSAGES OF INTERFERON ON VIRUSES ON DIFFERENT STAGES OF CHRONIC HEPATITIS B
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Abstract
In this paper 97 HBsAG positive cases and 60 HBeAg positive cases of chronic hepatitis B were treated with small dosages of interferon for one to six months. The viral targets were HBsAg HBeAg, anti-HBe, DNAP, HBV-DNA, After one month of post-treatment, six targets had not improved conspicuously in 97 cases. After two months of post-treatment, DNAP and HBeAg positive rates declined conspicuously in only 77 cases of disease, 5 viral targets all showed a statistically signifi cant decline for HBV-DNA from 73....
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Proportional views
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