COMPARATIVE STUDIES OF INFLUENZA (H_3N_2) ISOLATED FROM PIG AND HUMANⅠ. Analysis of Antigenicity and Polypeptide Structure of H_3N_2 Influenza Viruses

TIAN Mu-Zhen; LUO Qun-Ming; YAN Jia-Xin; LIN Qiao; FENG Ling-Ling

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February 1987

TIAN Mu-Zhen, LUO Qun-Ming, YAN Jia-Xin, LIN Qiao and FENG Ling-Ling. COMPARATIVE STUDIES OF INFLUENZA (H_3N_2) ISOLATED FROM PIG AND HUMANⅠ. Analysis of Antigenicity and Polypeptide Structure of H_3N_2 Influenza Viruses[J]. Virologica Sinica, 1987, 2(1).

Citation: TIAN Mu-Zhen, LUO Qun-Ming, YAN Jia-Xin, LIN Qiao, FENG Ling-Ling. COMPARATIVE STUDIES OF INFLUENZA (H_3N_2) ISOLATED FROM PIG AND HUMANⅠ. Analysis of Antigenicity and Polypeptide Structure of H_3N_2 Influenza Viruses .VIROLOGICA SINICA, 1987, 2(1) : 9.

猪与人甲_3型流感病毒的比较研究Ⅰ、抗原性及多肽结构分析

1.
湖北省医学科学院病毒研究所
2.
湖北省医学科学院病毒研究所武汉同济医科大学附属协和医院病毒研究室

摘要

比较1978、81、82年从猪中分离出的甲_3流感病毒与同年代人甲_3流感病毒的抗原性及多肽结耕。从血清学、血凝素肽图以及SDS-PAGE电泳图都表明逐年猪甲_3与人甲_3血凝素(HA)及神经氨酸酶(NA)抗原性密切相关。而且膜蛋白与核蛋白也基本相同。更明确表明人的甲_3流感病毒年年不断地极易传给猪。猪中有了甲_3病毒株其NP迁移位置与其它毒株略有不同,文中对此进行了讨论。用~(125)I标记血凝素肽图比较1979、1981、1982、1983年猪与人甲_3毒株,逐年在肽图上都有明显差异,同年不同时间分离的毒株之间,肽图上也略有改变,更进一步表明此法的灵敏性。

COMPARATIVE STUDIES OF INFLUENZA (H_3N_2) ISOLATED FROM PIG AND HUMANⅠ. Analysis of Antigenicity and Polypeptide Structure of H_3N_2 Influenza Viruses

1.
Virology Institute
2.
Hubei Academy of Medical Sciences

Abstract

Comparision of influenza A (H_3N_2) viruses isolated from pig and human in 19791932 in respect to antigenic analysis, SDS-polyacrylamide gel electrophoreses and haemagglutinin maps has been studied. The isolates from pigs each year were very closely related to contemporary human isolates. The surface antigens, HA and NA, as well as the matrix proteins (MP) and nucleoproteins (NP) were very similar, The present findings provided some evidences for the very frequent transmission of influenza (H_3N_2) from hu...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

COMPARATIVE STUDIES OF INFLUENZA (H_3N_2) ISOLATED FROM PIG AND HUMANⅠ. Analysis of Antigenicity and Polypeptide Structure of H_3N_2 Influenza Viruses

1. Virology Institute
2. Hubei Academy of Medical Sciences

Abstract: Comparision of influenza A (H_3N_2) viruses isolated from pig and human in 19791932 in respect to antigenic analysis, SDS-polyacrylamide gel electrophoreses and haemagglutinin maps has been studied. The isolates from pigs each year were very closely related to contemporary human isolates. The surface antigens, HA and NA, as well as the matrix proteins (MP) and nucleoproteins (NP) were very similar, The present findings provided some evidences for the very frequent transmission of influenza (H_3N_2) from hu...