THE FOLLOWED-UP OBSERVATION OF ANTIVIRAL TREATMENT WITH SMALL DOSE INTERFERON IN CHRONIC HEPATITIS B

HUANG Hua-Fang; XIONG Kai-Jun; WANG Xin-He; JIN Wei-E; ZENG Lian-Lan; WU Zhang-Qi

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August 1987

HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, JIN Wei-E, ZENG Lian-Lan and WU Zhang-Qi. THE FOLLOWED-UP OBSERVATION OF ANTIVIRAL TREATMENT WITH SMALL DOSE INTERFERON IN CHRONIC HEPATITIS B[J]. Virologica Sinica, 1987, 2(4).

Citation: HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, JIN Wei-E, ZENG Lian-Lan, WU Zhang-Qi. THE FOLLOWED-UP OBSERVATION OF ANTIVIRAL TREATMENT WITH SMALL DOSE INTERFERON IN CHRONIC HEPATITIS B .VIROLOGICA SINICA, 1987, 2(4) : 34.

小剂量干扰素对慢性乙型肝炎抗病毒治疗的追踪观察

1.
同济医科大学附属协和医院传染病教研室
2.
中国科学院武汉病毒研究所武汉

摘要

本文对40例曾经小剂量干扰素治疗、疗程达6个月的慢性乙肝患者进行治后6～20个月的追踪观察。从HBV标志物阴转率来看,抗病毒远期疗效结果为HBeAg治前19例阳性中,12例阴转(63.1％),其中6例并出现抗-HBe转阳。DNA-P治前3例阳性中,2例阴转(66.6％)。HBcAg治前2例阳性者也阴转。HBV-DNA治前3例阳性者仅一例阴转。HBsAg 39例阳性中,7例阴转(17.9％)。其中HBeAg及DNA-p阴转率较突出,分别为63.1％及66.6％。再从抗病毒综合反应来看,远期总有效率达57.5％(23/40),其中3例在治后14、15及20个月观察时:HBsAg、HBeAg、HBcAg、DNA-P及HBV-DNA均阴性。对照组20例HBsAg、HBeAg及DNA-P阴转率分别为0％、22.2％及0％。可见并非自然阴转,而是药物作用所致。由此认为小剂量干扰素对抗慢性乙肝病毒远期疗效是可取的,值得深入研究。

THE FOLLOWED-UP OBSERVATION OF ANTIVIRAL TREATMENT WITH SMALL DOSE INTERFERON IN CHRONIC HEPATITIS B

1.
Department of Infectious Disease
2.
Xiehe Hospital

Abstract

In this paper, followed-up observation during 6-20 months was taken on 40 cases with chronic hepatitis B, who have been treated with small dose interferon in a period of 6 months. Observation from the further effect of the negative percentage of HBV marker showed the results as follows: 12 of 19 HBeAg positive cases turned into negative(63.1％), anti-HBe positive appeared in6cases; 2 of 3 cases with DNA-P positive became negative(66.6％),2 cases with HBcAg positive became negative 1 of 3 cases with HBV-DNA po...

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

THE FOLLOWED-UP OBSERVATION OF ANTIVIRAL TREATMENT WITH SMALL DOSE INTERFERON IN CHRONIC HEPATITIS B

1. Department of Infectious Disease
2. Xiehe Hospital

Abstract: In this paper, followed-up observation during 6-20 months was taken on 40 cases with chronic hepatitis B, who have been treated with small dose interferon in a period of 6 months. Observation from the further effect of the negative percentage of HBV marker showed the results as follows: 12 of 19 HBeAg positive cases turned into negative(63.1％), anti-HBe positive appeared in6cases; 2 of 3 cases with DNA-P positive became negative(66.6％),2 cases with HBcAg positive became negative 1 of 3 cases with HBV-DNA po...