Experiment on the Oncogenicity of Cell Lines Transformed by Herpes Simplex Virus

CHEN Chen-Hua; ZENG Li; DONG Jie-De; SONG Yuan-Di; FAN Bo-Xun; CAO Zong-Li; CHOU Su-Ying; XU Xiu-Ping

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April 1988

CHEN Chen-Hua, ZENG Li, DONG Jie-De, SONG Yuan-Di, FAN Bo-Xun, CAO Zong-Li, CHOU Su-Ying and XU Xiu-Ping. Experiment on the Oncogenicity of Cell Lines Transformed by Herpes Simplex Virus[J]. Virologica Sinica, 1988, 3(2).

Citation: CHEN Chen-Hua, ZENG Li, DONG Jie-De, SONG Yuan-Di, FAN Bo-Xun, CAO Zong-Li, CHOU Su-Ying, XU Xiu-Ping. Experiment on the Oncogenicity of Cell Lines Transformed by Herpes Simplex Virus .VIROLOGICA SINICA, 1988, 3(2) : 136.

单纯疱疹病毒Ⅱ型转化人胚肺细胞在裸鼠体内成瘤实验

1.
山东医科大学微生物学教研室
2.
山东医科大学微生物学教研室济南

摘要

对三系转化的人胚肺细胞,分别在裸鼠体内进行了成瘤试验。其中两系转化细胞(29—33代)的成瘤率达100％,另一系(47代)为66％。转化细胞诱生的肿瘤生长迅速,局部瘤可循淋巴转移。瘤细胞可在裸鼠体内传代。瘤细胞形态学检查证实为低分化癌。该细胞带有HSV抗原。

Experiment on the Oncogenicity of Cell Lines Transformed by Herpes Simplex Virus

1.
Department of Microbiology: Shandong Medical University: Jinan

Abstract

The capacity of three cell lines transformed by HSV-2 to induce tumours in nude mice was studied. The results indicate: (1) The transformed cell lines of the 29-30th passage were oncogenic in nude mice with 100％ positive rate. The other lines of the 47th passage was also oncogenic with 66％ positive rate. (2) The induced tumours grew very rapidly and metastasized to the drainig lymph nodes. (3) The tumours could be transplanted successfully from animal to animal. (4) Morphologically, the tumours were highly ...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Experiment on the Oncogenicity of Cell Lines Transformed by Herpes Simplex Virus

1. Department of Microbiology: Shandong Medical University: Jinan

Abstract: The capacity of three cell lines transformed by HSV-2 to induce tumours in nude mice was studied. The results indicate: (1) The transformed cell lines of the 29-30th passage were oncogenic in nude mice with 100％ positive rate. The other lines of the 47th passage was also oncogenic with 66％ positive rate. (2) The induced tumours grew very rapidly and metastasized to the drainig lymph nodes. (3) The tumours could be transplanted successfully from animal to animal. (4) Morphologically, the tumours were highly ...