Study on the Hamster Infected with Epidemic Hemorrhagic Fever Virus

ZHU Zhi-Yong; LI Yan-Jin; TANG Han-Yang; WENG Jing-Qing; FU Gui-Meng; TAO Shun-Rong; YU Yong-Xin; DONG Guan-Mu

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June 1988

ZHU Zhi-Yong, LI Yan-Jin, TANG Han-Yang, WENG Jing-Qing, FU Gui-Meng, TAO Shun-Rong, YU Yong-Xin and DONG Guan-Mu. Study on the Hamster Infected with Epidemic Hemorrhagic Fever Virus[J]. Virologica Sinica, 1988, 3(3).

Citation: ZHU Zhi-Yong, LI Yan-Jin, TANG Han-Yang, WENG Jing-Qing, FU Gui-Meng, TAO Shun-Rong, YU Yong-Xin, DONG Guan-Mu. Study on the Hamster Infected with Epidemic Hemorrhagic Fever Virus .VIROLOGICA SINICA, 1988, 3(3) : 249.

流行性出血热病毒感染金黄地鼠的实验研究

1.
浙江省卫生防疫站
2.
卫生部药品生物制品检定所
3.
卫生部药品生物制品检定所杭州

摘要

本文证明金黄地鼠对于流行性出血热病毒包括家鼠型和野鼠型毒株均敏感。除口饲外,多途径接种均可使地鼠感染。流行性出血热病毒浙5株10001D_(50)接种3周龄地鼠,五天后即可在肺、脾、肠、肝等多种组织中检出病害抗原,至8—10天达最峰,其中肺最强,抗原持续时间至少50天。接种病毒后10天左右,可在血中检出抗体,后缓慢上升,至第50天达1:1280—1:5120。乳鼠感染EHF病毒后可引起全身播散性感染,病毒抗原可在全身软组织中找到。乳鼠感染强毒株可发病致死,但幼鼠和成鼠不表现症状为健康带毒者。

Study on the Hamster Infected with Epidemic Hemorrhagic Fever Virus

1.
Zhejiang Health and Anti-epidemic Station
2.
HangzhouNational Institute for the Contrel of Pharmaceutical and Biological Products
3.
Beijing

Abstract

It was shown in our study the hamster is susceptible to Epidemic Hemor- rhagic Fever Virus(EHFV) including the wild-mouse type(strains Z_3, Z_4, Z_5, Z_(10), 76—118) and the house-rat type(strains Z_(26), R_(22), SR-11,Z_(30),Z_(34)). The hamster was successfully infected intramuscularly, intraperitoneally, subcutaneously and intrapulmonaryly or intracerebrally (suckling hamster) but not orally. EHFV antigen appeared in lung 5 days after inoculation of EHFV strain Z_5 and persisted for at least 50 days.EHFV...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study on the Hamster Infected with Epidemic Hemorrhagic Fever Virus

1. Zhejiang Health and Anti-epidemic Station
2. HangzhouNational Institute for the Contrel of Pharmaceutical and Biological Products
3. Beijing

Abstract: It was shown in our study the hamster is susceptible to Epidemic Hemor- rhagic Fever Virus(EHFV) including the wild-mouse type(strains Z_3, Z_4, Z_5, Z_(10), 76—118) and the house-rat type(strains Z_(26), R_(22), SR-11,Z_(30),Z_(34)). The hamster was successfully infected intramuscularly, intraperitoneally, subcutaneously and intrapulmonaryly or intracerebrally (suckling hamster) but not orally. EHFV antigen appeared in lung 5 days after inoculation of EHFV strain Z_5 and persisted for at least 50 days.EHFV...