Researches on Pre-S Proteins of Hepatitis B Virus Ⅵ. Binding of Pre-S Proteins with Human Serum Albumin

HU Ke-Qin; YU Zhi-Qun; ZHANG Yong-Yuan; LI Fang-He; HAO Lian-Jie

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April 1989

HU Ke-Qin, YU Zhi-Qun, ZHANG Yong-Yuan, LI Fang-He and HAO Lian-Jie. Researches on Pre-S Proteins of Hepatitis B Virus Ⅵ. Binding of Pre-S Proteins with Human Serum Albumin[J]. Virologica Sinica, 1989, 4(2).

Citation: HU Ke-Qin, YU Zhi-Qun, ZHANG Yong-Yuan, LI Fang-He, HAO Lian-Jie. Researches on Pre-S Proteins of Hepatitis B Virus Ⅵ. Binding of Pre-S Proteins with Human Serum Albumin .VIROLOGICA SINICA, 1989, 4(2) : 159.

乙型肝炎病毒前S蛋白的研究——Ⅵ.前S蛋白与人血清白蛋白的结合

1.
同济医科大学同济医院临床免疫研究室
2.
同济医科大学同济医院临床免疫研究室武汉

摘要

本文观察了40份HBV感染者血清前S_1、前S_2与PHSAR的关系,结果表明前S_2可能是PHSA的主要结合部位,但前S_1可能也具有结合PHSA的活性。体外条件下PHSA可阻断前S_1、前S_2以及PHSAR活性,这种阻断效应与PHSA稀释度呈反相关系。本文还证实,HBV感染者血(?)内存在HBV外壳蛋白—HSA复合物,推测HSA与HBV外壳蛋白的结合可能是宿主抗HBV感染的免疫防御方式之一。
- 乙型肝炎病毒
- , 前S蛋白
- , 聚合人血清白蛋白受体
- , 人血清白蛋白

Researches on Pre-S Proteins of Hepatitis B Virus Ⅵ. Binding of Pre-S Proteins with Human Serum Albumin

1.
Division of Clinical Immunology
2.
Tongji Hospital

Abstract

40 serum samples were used to study the relation of Pre-S_1 and pre-S_2 proteins to polymerized human serum albumin receptor (PHSAR). Our results suggested that pre-S_2 may be the main binding site for PHSA, but pre-S_1 may also possess the activity to bind PHSA. Pre-S_1, pre-S_2 and PHSAR may be blocked in vitro by pretreatment with PHSA and the negative correlation between the blocking rate and the dilution of PHSA was seen. We also showed that the complexes of HBV envelop protein-human serum albumin may ...
- Hepatitis B virus
- , Pre-S proteins
- , Polymerized human serum albumin
- , Human serum albumin

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Researches on Pre-S Proteins of Hepatitis B Virus Ⅵ. Binding of Pre-S Proteins with Human Serum Albumin

1. Division of Clinical Immunology
2. Tongji Hospital

Abstract: 40 serum samples were used to study the relation of Pre-S_1 and pre-S_2 proteins to polymerized human serum albumin receptor (PHSAR). Our results suggested that pre-S_2 may be the main binding site for PHSA, but pre-S_1 may also possess the activity to bind PHSA. Pre-S_1, pre-S_2 and PHSAR may be blocked in vitro by pretreatment with PHSA and the negative correlation between the blocking rate and the dilution of PHSA was seen. We also showed that the complexes of HBV envelop protein-human serum albumin may ...