Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice

YAN Xiao; XIONG Hong-En

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June 1989

YAN Xiao and XIONG Hong-En. Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice[J]. Virologica Sinica, 1989, 4(3).

Citation: YAN Xiao, XIONG Hong-En. Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice .VIROLOGICA SINICA, 1989, 4(3) : 262.

(s)-DHPA在小白鼠乳鼠体内对流行性出血热病毒抑制作用的初步观察

言晓 ,
熊宏恩

1.
湖南医科大学第一临床学院传染病学教研室
2.
湖南医科大学第一临床学院传染病学教研室长沙

摘要

本文报道了(s)—9—(2,3-dihydroxypropyl)adenine(简称(s)-DHPA)对流行性出血热(EHF)病毒J_(10)株感染小白鼠乳鼠的影响。实验表明,两个(s)-DHPA治疗组感染乳鼠的发病率(44.44％、55.17％)和感染率(44.44％、55.17％)均较对照组的发病率(83.33％)和感染率(86.96％)明显降低。实验结果提示,(s)-DHPA具有一定的抑制EHF病毒在小白鼠乳鼠体内复制的作用,为临床开发治疗EHF的抗病毒新药提供了实验室依据。
- （s）-DHPA EHF病毒
- , 小白鼠乳鼠

Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice

YAN Xiao ,
XIONG Hong-En

1.
Department of Infectious Disease
2.
The First ffiliated Hospital

Abstract

The inhibitory effect of (s)-9-(2, 3-dihydroxypropyl) adenine ((s)-DHPA)on infection of Epidemic Hemorrhagic Fever Virus (EHFV) J10 strain in su-ckling mice was observed. The experimental results showed that the morbidityrate (44.44 % and 55.17%) and infection rate (44.44% and 55.17%) of two(s)-DHPA treatment groups were markedly lower than that of the control group(83.33% and 86.96% respectively). Their differences were statistically signi-ficant. These results suggested that EHFV replication in suckling m...
- （s）-DHPA
- , EHFV

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice

YAN Xiao ,
XIONG Hong-En

1. Department of Infectious Disease
2. The First ffiliated Hospital

Abstract: The inhibitory effect of (s)-9-(2, 3-dihydroxypropyl) adenine ((s)-DHPA)on infection of Epidemic Hemorrhagic Fever Virus (EHFV) J10 strain in su-ckling mice was observed. The experimental results showed that the morbidityrate (44.44 % and 55.17%) and infection rate (44.44% and 55.17%) of two(s)-DHPA treatment groups were markedly lower than that of the control group(83.33% and 86.96% respectively). Their differences were statistically signi-ficant. These results suggested that EHFV replication in suckling m...