Studies on Infection of Epidemic Hemorrhagic Fever Virus (EHFV) on Suckling-young Pigs

ZENG Gui-Jin; XIA Tie-Guo; ZHAO Yun-Shi; ZHAO Dong-Yan; FU Zhan-Guo

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August 1989

ZENG Gui-Jin, XIA Tie-Guo, ZHAO Yun-Shi, ZHAO Dong-Yan and FU Zhan-Guo. Studies on Infection of Epidemic Hemorrhagic Fever Virus (EHFV) on Suckling-young Pigs[J]. Virologica Sinica, 1989, 4(4).

Citation: ZENG Gui-Jin, XIA Tie-Guo, ZHAO Yun-Shi, ZHAO Dong-Yan, FU Zhan-Guo. Studies on Infection of Epidemic Hemorrhagic Fever Virus (EHFV) on Suckling-young Pigs .VIROLOGICA SINICA, 1989, 4(4) : 370.

流行性出血热病毒感染家猪的实验

1.
河南省卫生防疫站
2.
河南省新安县卫生防疫站
3.
河南省新安县卫生防疫站郑州

摘要

本实验证明猪为流行性出血热病毒(EHFV)的敏感实验动物。从啮齿动物中分离的动物源株(R_(22))和从EHF患者血中分离的人源株(HB_(55))都可感染猪,并可在其体内许多组织中复制增殖。家猪在接种EHFV后第6—9天有一个短暂的发烧期,表现出病毒血症。于接种后的第7—11天(R_(22))和7～20天(HB_(55))可在组织中、特别是脾和肺中,用直接免疫荧光技术(DFA)很容易地捡出EHFV抗原。亦可在感染EHFV的猪血中检出EHFV抗体。从感染后的荧光阳性猪脾、肺可分离出感染性病毒。但R_(22)病毒株在感染猪后的第15天便完全消失,而HB_(55)株在感染后的第20天仍可查见,似乎动物源株(R_(22))和人源株(HB_(55))有所差异,然而都对家猪有感染性。从而,首次证实了家猪为EHFV的敏感实验动物,可作为EHFV的分离,增殖及疫苗研制等的新动物模型。这一发现,对EHF的研究将起积极作用,也提示猪在EHF流行病学上的意义不可忽视。
- 仔猪
- , 流行性出血热病毒
- , 敏感动物

Studies on Infection of Epidemic Hemorrhagic Fever Virus (EHFV) on Suckling-young Pigs

1.
1. Henan Province Health and Anti-epidemic Station
2.
Zhengzhoitt Henan 2. Xin-an County Sanitary and Anti-epidemic Station
3.
Xin-an

Abstract

This study confirmed that suckling young pig is a laboratory animal susceptible to EHFV strains R22 and HB55 isolated from wild rodents and patients with EHF. The study showed that EHFV was able to propagate in many tissues of pigs, Viremia appeared in suckling young pigs on 6—9th days after inoculation of EHFV. Specific fluorescence for EHFV antigen was detected in many tissues, especially in spleen and lung on 7—11th and 7—20th day of experimental infection. Pigs infected with EHFV developed high titre an...
- Suckling young pig
- , Epidemic hemorrhagic fever virus
- , Sensitivity animal

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Studies on Infection of Epidemic Hemorrhagic Fever Virus (EHFV) on Suckling-young Pigs

1. 1. Henan Province Health and Anti-epidemic Station
2. Zhengzhoitt Henan 2. Xin-an County Sanitary and Anti-epidemic Station
3. Xin-an

Abstract: This study confirmed that suckling young pig is a laboratory animal susceptible to EHFV strains R22 and HB55 isolated from wild rodents and patients with EHF. The study showed that EHFV was able to propagate in many tissues of pigs, Viremia appeared in suckling young pigs on 6—9th days after inoculation of EHFV. Specific fluorescence for EHFV antigen was detected in many tissues, especially in spleen and lung on 7—11th and 7—20th day of experimental infection. Pigs infected with EHFV developed high titre an...