Reactive Observation of Inactivated Epidemic Hemorrhagic Fever Vaccine in Human Test

ZHU Zhi-Yong; TANG Han-Ying; LI Yan-Jin; WENG Jing-Qing; FU Gui-Ming; SHU Yong-Xin; YAO Xiao-Jian; DONG Guan-Mu; AN Qi; ZENG Rong-Fang; CHEN Song-Nian; WANG Guo-Mei; SHEN Wei

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February 1990

ZHU Zhi-Yong, TANG Han-Ying, LI Yan-Jin, WENG Jing-Qing, FU Gui-Ming, SHU Yong-Xin, YAO Xiao-Jian, DONG Guan-Mu, AN Qi, ZENG Rong-Fang, CHEN Song-Nian, WANG Guo-Mei and SHEN Wei. Reactive Observation of Inactivated Epidemic Hemorrhagic Fever Vaccine in Human Test[J]. Virologica Sinica, 1990, 5(1).

Citation: ZHU Zhi-Yong, TANG Han-Ying, LI Yan-Jin, WENG Jing-Qing, FU Gui-Ming, SHU Yong-Xin, YAO Xiao-Jian, DONG Guan-Mu, AN Qi, ZENG Rong-Fang, CHEN Song-Nian, WANG Guo-Mei, SHEN Wei. Reactive Observation of Inactivated Epidemic Hemorrhagic Fever Vaccine in Human Test .VIROLOGICA SINICA, 1990, 5(1) : 7.

流行性出血热灭活疫苗人体试验的反应观察

1.
浙江省卫生防疫站自然疫源科
2.
中国药品生物制品检定所疫苗一室
3.
上海生物制品研究所病毒研究室
4.
上海生物制品研究所病毒研究室杭州

摘要

由流行性出血热(EHF)病毒浙_(10)株感染沙鼠肾细胞,经0.05％β-丙内酯灭活研制成的EHF灭活疫苗,于4℃放置7个月后,对10名志愿者免疫三针(0天、7天、28天各注射1ml)。结果免疫者的局部和全身均无任何副反应。首针免疫后第28天,血清用反向被动血凝抑制试验(RPHIA)、ELISA和间接免疫荧光试验(IFA)检测EHF抗体,分别有9人、9人和8人阳转,第42天,血清用三种方法检测抗体均全部阳转。空斑减少中和试验(PRNT)于第28天有4人阳转,第42天有9人阳转。上述结果表明,此疫苗对人体有较好的的安全性和免疫原性。
- 流行性出血热灭活疫苗
- , 人体试验

Reactive Observation of Inactivated Epidemic Hemorrhagic Fever Vaccine in Human Test

1.
Zheiiang Health and Anti-epidemic Station
2.
Hangzhou 310309 National Institute for the Control of pharmaceutical and Biological products
3.
Beijing Shanghai Institute of Biological Products
4.
Shanghai

Abstract

Ten volunteers had been immunized intramuscularly(1 ml) three times at the 0, 7 and 28 days with the inactivatated(with 0.05%β-propiolactone) EHF Meriones unguiciculatus kidney culture vaccine with Z_(10) virus strain (kept at 4℃ for 7 months). The result showed that there had not been any side effects locally and generally in all of the volunteers. The EHF virus antibodies were detected in 9 and 8 volunteers with IFA and ELISA methods respectively and 9 volunteers were positive with RPHIA. And 4 volunteers...
- Inactivated EHF vaccine
- , Human test

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Reactive Observation of Inactivated Epidemic Hemorrhagic Fever Vaccine in Human Test

1. Zheiiang Health and Anti-epidemic Station
2. Hangzhou 310309 National Institute for the Control of pharmaceutical and Biological products
3. Beijing Shanghai Institute of Biological Products
4. Shanghai

Abstract: Ten volunteers had been immunized intramuscularly(1 ml) three times at the 0, 7 and 28 days with the inactivatated(with 0.05%β-propiolactone) EHF Meriones unguiciculatus kidney culture vaccine with Z_(10) virus strain (kept at 4℃ for 7 months). The result showed that there had not been any side effects locally and generally in all of the volunteers. The EHF virus antibodies were detected in 9 and 8 volunteers with IFA and ELISA methods respectively and 9 volunteers were positive with RPHIA. And 4 volunteers...