HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, CENG Lian-Lan, LIU Bi-Xi, CENG Fan-Zhen and TUN Zhang-Qi. Followed-up Observation on Antiviral Effect of Combined Treatment of Small Dosage of Interferon and Thymosin in Patients with Chronic Hepatitis B[J]. Virologica Sinica, 1990, 5(1).
Citation:
HUANG Hua-Fang, XIONG Kai-Jun, WANG Xin-He, CENG Lian-Lan, LIU Bi-Xi, CENG Fan-Zhen, TUN Zhang-Qi.
Followed-up Observation on Antiviral Effect of Combined Treatment of Small Dosage of Interferon and Thymosin in Patients with Chronic Hepatitis B .VIROLOGICA SINICA, 1990, 5(1)
: 69.
小剂量干扰素与胸腺肽联合对慢性乙型肝炎抗病毒效应的追踪观察
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1.
同济医科大学附属协和医院传染病教研组
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2.
同济医科大学附属协和医院检验科
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3.
卫生部武汉生物制品所
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4.
中国科学院武汉病毒研究所 武汉
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摘要
本文报道小剂量干扰素与胸腺肽联合对慢性乙肝20例抗病毒效应的追踪观察结果,并与同期同批同剂量单纯干扰素治疗13例慢性乙肝作对照,追踪时间均为治后半年—2年,从HBeAg、HBcAg、DNAP、HBV DNA阴转率来看,治疗组分别为58.8%、60%、60%及66.6%、对照组分别为50%、50%、100%及50%。再从HBV四项复制指标改变来看,则治疗组4例全阴转,7例仅一项阳性,总有效率达61.1%(11/18),而对照组仅为20%(2/10),P<0.01,认为干扰素与胸腺肽联合治疗优于对照组,并扼要讨论增强干扰素抗病毒效应的各种措施,认为干扰素与胸腺肽联合,不论从前已报道近期疗效和本文远期追踪来看均较安全而有效,二者合用起到增强抗病毒效应的作用,值得进一步探索。
Followed-up Observation on Antiviral Effect of Combined Treatment of Small Dosage of Interferon and Thymosin in Patients with Chronic Hepatitis B
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1.
Department of Infectious Disease
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2.
Union Hospital
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3.
Tongji Medical University
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4.
Wuhan. 430022Wuhan Bio-products Institute WuhanWuhan Institute of Virology
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Abstract
In this paper, followed-up observation during half to 2 years was taken in 20 cases with chronic hepatitis B who had been treated by combining small dosage of interferon with thymosin. Another 13 cases of chronic hepatitis B were treated only with interferon in the same dosage and period. The results showed that the negative percentage of HBeAg, HBeAg, DNAP, HBV-DNA were 58.8%, 60%, 60% and 66.6% respectively in the treated group. In the contrast group, the negative percentage of the same marks was 50%, 50%...
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References
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Proportional views
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