QU Chun-Feng, Yang Tie-Qiu and Xiang Jin-Min. Pathogenicity of Epidemic Hemorrhagic Fever Virus in Suckling Mice[J]. Virologica Sinica, 1990, 5(2).
Citation: QU Chun-Feng, Yang Tie-Qiu, Xiang Jin-Min. Pathogenicity of Epidemic Hemorrhagic Fever Virus in Suckling Mice .VIROLOGICA SINICA, 1990, 5(2) : 157.

流行性出血热病毒对乳鼠致病特点的观察

  • 本文观察了两株从病人体内新分离的流行性出血热(EHF)病毒114株和435株对乳鼠的致病特点,并在感染的乳鼠脑内找到了EHF病毒。免疫荧光检查发现,病毒抗原广泛存在于感染鼠的脑、肺、肝、肾等脏器。脑内和腹腔两条感染途径的比较发现,病毒抗原在上述脏器中的分布基本一致,但前者脑内的病毒感染滴度较后者高一个对数单位。对病毒的动态观察发现,EHF病毒首先在乳鼠腹腔感染6小时后的腹腔巨噬细胞(Mφ)中分离到、并持续阳性;病毒血症出现在感染后2天,随之在脑、肺、肝、肾和脾脏中查到。以上结果表明:EHF病毒对乳鼠具有广泛的嗜性,脑内感染途径能获得较高滴度的感染性病毒。提示EHF病毒在鼠mφ中增殖并携带至全身播散,可能是造成乳鼠全身性弥漫性感染的主要原因。

Pathogenicity of Epidemic Hemorrhagic Fever Virus in Suckling Mice

  • It was observed that two strains EHF virus which were isolated newly from patients had pathogenicity on suckling mice.The EHF virus particles were found in the infected mice brain under electron microscope.On IF examination viral antigen could be found in brain, lungs, liver, kidneys and other organs.Comparing intracerebral with intrapertoneal inoculation, it was found that there is no appaerent difference in viral antigen distribution.But the infectious virus titre of brain in the former was one logarithm ...

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    Pathogenicity of Epidemic Hemorrhagic Fever Virus in Suckling Mice

    • 1. Virus Research Institute
    • 2. Hubei Medical College

    Abstract: It was observed that two strains EHF virus which were isolated newly from patients had pathogenicity on suckling mice.The EHF virus particles were found in the infected mice brain under electron microscope.On IF examination viral antigen could be found in brain, lungs, liver, kidneys and other organs.Comparing intracerebral with intrapertoneal inoculation, it was found that there is no appaerent difference in viral antigen distribution.But the infectious virus titre of brain in the former was one logarithm ...

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