Histopathological Features of Patients with Intrahepatic HDAg-positive Chronic Hepatitis

ZHANG Yong-Dong; ZHANG Yong-Yuan

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August 1990

ZHANG Yong-Dong and ZHANG Yong-Yuan. Histopathological Features of Patients with Intrahepatic HDAg-positive Chronic Hepatitis[J]. Virologica Sinica, 1990, 5(4).

Citation: ZHANG Yong-Dong, ZHANG Yong-Yuan. Histopathological Features of Patients with Intrahepatic HDAg-positive Chronic Hepatitis .VIROLOGICA SINICA, 1990, 5(4) : 352.

肝内HDAg阳性慢性肝炎病理特点探讨

张永东 ,
张永源

1.
武汉市传染病医院病理室
2.
同济医院临床免疫研究室武汉

摘要

用直接酶标和直接免疫荧光法在120例HBsAg阳性肝组织中检测HDAg,发现5例阳性(4.2％),其中3例活动性肝硬化,2例慢性中型活动性肝炎。另设立相对应的单纯乙型肝炎作为对照,通过光镜、电镜、免疫组化的方法,重点探讨比较丁型肝炎与单纯乙型肝炎二者肝组织学的形态变化。丁型肝炎组肝细胞灶状坏死,桥接坏死,融合性坏死的程度比单纯乙型肝炎组重,丁型肝炎组较单纯乙型肝炎组常见的组织学改变是肝细胞呈灶状微小空泡的脂肪变性及灶状嗜酸性变性。HDAg阳性肝细胞呈疏松化、核固缩,其周围未见淋巴细胞浸润。
- HDAg
- , HBsAg
- , 免疫组化
- , 丁型肝炎

Histopathological Features of Patients with Intrahepatic HDAg-positive Chronic Hepatitis

1.
Dept.of Pathology
2.
Wuhan Infectious Diseases Hospital

Abstract

To explore the histopathological features in chronic hepatitis D, 5 out of 120 cases of HBsAg-positive liver samples were found to be intrahepatitic HDAg-positive by direct immunof luorescence and immunoperoxidase assays. Among 5 cases, 3 had active cirrhosis, 2 cases with chronic active hepatitis. Wellmatched cases with chronic hepatitis B were used as control, Emphasis was put on similarity and difference in histopathological findings between hepatitis D and hepatitis B by light and electron microscopy an...
- HDAg
- , HBsAg
- , Immunohistochemistry
- , Hepatitis D

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Histopathological Features of Patients with Intrahepatic HDAg-positive Chronic Hepatitis

1. Dept.of Pathology
2. Wuhan Infectious Diseases Hospital

Abstract: To explore the histopathological features in chronic hepatitis D, 5 out of 120 cases of HBsAg-positive liver samples were found to be intrahepatitic HDAg-positive by direct immunof luorescence and immunoperoxidase assays. Among 5 cases, 3 had active cirrhosis, 2 cases with chronic active hepatitis. Wellmatched cases with chronic hepatitis B were used as control, Emphasis was put on similarity and difference in histopathological findings between hepatitis D and hepatitis B by light and electron microscopy an...