Studies on Antiviral Activity of the Extract of Monordica Charantca and its Active Principle

HUANG Tian-Min; XU Zhao-Xiang; WANG Yan-Ping; QU Feng-Zhen; TONG Ling-Li

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August 1990

HUANG Tian-Min, XU Zhao-Xiang, WANG Yan-Ping, QU Feng-Zhen and TONG Ling-Li. Studies on Antiviral Activity of the Extract of Monordica Charantca and its Active Principle[J]. Virologica Sinica, 1990, 5(4).

Citation: HUANG Tian-Min, XU Zhao-Xiang, WANG Yan-Ping, QU Feng-Zhen, TONG Ling-Li. Studies on Antiviral Activity of the Extract of Monordica Charantca and its Active Principle .VIROLOGICA SINICA, 1990, 5(4) : 367.

苦瓜提取物抗病毒作用及其有效成份的研究

1.
中国预防医学科学院病毒研究所
2.
中国预防医学科学院病毒研究所北京

摘要

本实验发现,小鼠皮下感染乙型脑炎病毒前腹腔注射苦瓜提取物(简称E.M.c.)有显著的保护作用,其保护率平均为66％;以E.M.c.静脉注射家兔后2小时,血清中的干扰素达高峰,其干扰素为I型干扰素;E.M.c.对小鼠NK细胞有明显的激活作用;经鉴定,E.M.c.中的有效成份主要是dsRNA,此外,还含有多糖类物质。
- 抗病毒活性
- , 苦瓜提取物
- , 乙型脑炎病毒
- , 干扰素诱生剂
- , 双链
- , 核糖核酸
- , 自然杀伤细胞

Studies on Antiviral Activity of the Extract of Monordica Charantca and its Active Principle

1.
Institute of Virology
2.
Chinese Academy of Preventive Medicine

Abstract

The extract of Monordica charantia (E. M. c.) was found to have a significant protective effect on Japanese B encephlitis virus infection in vivo. When mice were administered intraperitoneally with a dose of 0.4 mg E. M. c. at 18 hr, 12 hr, 4 hr before subcutaneous challenge with the virus respectively, the protective rate of treated group is 66%. E.M.c. was demonstrated as an interferon inducer. Type I IFN was found in rabbit serum and its level peaked at 2hr after intravenus injection of E. M.c. E.M.c. en...
- Antiviral activity
- , Extract of Monordica charantia Japanese B encephalitis virus
- , Interferon inducer
- , dsRNA
- , NK cell

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Studies on Antiviral Activity of the Extract of Monordica Charantca and its Active Principle

1. Institute of Virology
2. Chinese Academy of Preventive Medicine

Abstract: The extract of Monordica charantia (E. M. c.) was found to have a significant protective effect on Japanese B encephlitis virus infection in vivo. When mice were administered intraperitoneally with a dose of 0.4 mg E. M. c. at 18 hr, 12 hr, 4 hr before subcutaneous challenge with the virus respectively, the protective rate of treated group is 66%. E.M.c. was demonstrated as an interferon inducer. Type I IFN was found in rabbit serum and its level peaked at 2hr after intravenus injection of E. M.c. E.M.c. en...