Study on Viremia of the Rabbits Infected with EHFV-H114 Strain

BANG Gong-Mei; LIN Yu-Lin; GAO You-Xin; XIANG Jin-Min

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August 1990

BANG Gong-Mei, LIN Yu-Lin, GAO You-Xin and XIANG Jin-Min. Study on Viremia of the Rabbits Infected with EHFV-H114 Strain[J]. Virologica Sinica, 1990, 5(4).

Citation: BANG Gong-Mei, LIN Yu-Lin, GAO You-Xin, XIANG Jin-Min. Study on Viremia of the Rabbits Infected with EHFV-H114 Strain .VIROLOGICA SINICA, 1990, 5(4) : 373.

感染流行性出血热病毒家兔病毒血症的研究

1.
湖北医学院附一医院检验科
2.
湖北医学院病毒研究所
3.
湖北医学院病毒研究所武汉

摘要

本文采用流行性出血热病毒114株实验感染家兔,用免疫荧光法及病毒培养技术研究了家兔病毒血症动态,发现感染后第6天,病毒抗原首先在淋巴细胞及单核细胞中出现;次日,亦可见于粒细胞中,第10—12天的抗原反应较强,第15天则明显减弱至消失。而在红细胞及血小板中始终未见明显的抗原反应。从感染后第3—13天的血浆中分离出病毒;感染后第6—15天,外周血单核细胞病毒分离阳性。结果表明,流行性出血热病毒在接种局部增殖后,侵入血液,并在白细胞中复制增殖,可能使病毒随血循环播散至全身其它组织脏器,造成因血传播引起的靶器官感染。
- 流行性出血热病毒
- , 家兔
- , 病毒血症

Study on Viremia of the Rabbits Infected with EHFV-H114 Strain

1.
Virus research institute
2.
Hubei medical college
3.
Wuhan 430071

Abstract

Rabbits were inoculated with EHFV-H 114 strain isolated from urine of the patient with EHF in the acute phase. The duration of viremic stage of rabbits infected with EHFV-H114 was studied by means of immunoflourescent technique and culture assays. Specific flourescence for EHFV antigen was first observed in both monocytes and lymphocytes on the 6th day, the next day, also was seen in granulocytes, with the strongest antigen reaction on the 10-12th days, and dissappeared on the 15th day of experimental infec...
- Epidemic hemorrhagic fever virus
- , Rabbit
- , Viremia

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study on Viremia of the Rabbits Infected with EHFV-H114 Strain

1. Virus research institute
2. Hubei medical college
3. Wuhan 430071

Abstract: Rabbits were inoculated with EHFV-H 114 strain isolated from urine of the patient with EHF in the acute phase. The duration of viremic stage of rabbits infected with EHFV-H114 was studied by means of immunoflourescent technique and culture assays. Specific flourescence for EHFV antigen was first observed in both monocytes and lymphocytes on the 6th day, the next day, also was seen in granulocytes, with the strongest antigen reaction on the 10-12th days, and dissappeared on the 15th day of experimental infec...