ENG Lian-Lan, XIONG Kai-Jun, HUANG Hua-Fang, HE Sheng-Song, LUO Duan-De, WANG Xin-He, DAI Jia-Zhu and LIU Hong-Yan. Study on Intercellular Virus Replication in the Patients Continually Infected by Hepatitis B Virus[J]. Virologica Sinica, 1991, 6(1).
Citation: ENG Lian-Lan, XIONG Kai-Jun, HUANG Hua-Fang, HE Sheng-Song, LUO Duan-De, WANG Xin-He, DAI Jia-Zhu, LIU Hong-Yan. Study on Intercellular Virus Replication in the Patients Continually Infected by Hepatitis B Virus .VIROLOGICA SINICA, 1991, 6(1) : 43.

乙型肝炎病毒持续感染患者细胞内病毒复制的研究

  • 用Southern blot技术对乙肝病毒感染肝脏和外周血白细胞的情况进行了对比研究,发现白细胞的阳性率为44%,肝组织的阳性率为46%,两者无统计学差异。根据琼脂糖凝胶电泳速度可将病毒DNA分子分为游离型、整合型和混合型,配对检查两者亦无明确相关性,说明外周血白细胞是乙肝病毒攻击的靶细胞,亦是病毒复制的场所。白细胞中病毒DNA游离型与血清学指标HBeAg(+),HBV DNA斑点杂交(+)关系密切,而整合型除与上述指标有关外,还和抗-HBe(+)有关,表明病毒在乙肝发病过程中复制和部分静止的差异。

Study on Intercellular Virus Replication in the Patients Continually Infected by Hepatitis B Virus

  • The status of livers and white blood cells in peripheral blood after infected with hepatitis B virus were studied by Southern blot technique. The positive rate was 44% in white blood cells and 46% in the livers, respectively. There was no significant different beween them. According to speed of agarose gel electrophoresis, DNA fragments of virus can be divided into three types, namely free, integrated and mixed types. There was atso no significance. These results suggested that white blood cells were target...

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    Study on Intercellular Virus Replication in the Patients Continually Infected by Hepatitis B Virus

    • 1. Department of Infectious Diseases
    • 2. Xiehe Hospital

    Abstract: The status of livers and white blood cells in peripheral blood after infected with hepatitis B virus were studied by Southern blot technique. The positive rate was 44% in white blood cells and 46% in the livers, respectively. There was no significant different beween them. According to speed of agarose gel electrophoresis, DNA fragments of virus can be divided into three types, namely free, integrated and mixed types. There was atso no significance. These results suggested that white blood cells were target...

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