Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3

YU Yong-Xin; AN Qi; YAO Zhi-Hui; HE Hao; SHU Zhi-Yong

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June 1991

YU Yong-Xin, AN Qi, YAO Zhi-Hui, HE Hao and SHU Zhi-Yong. Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3[J]. Virologica Sinica, 1991, 6(3).

Citation: YU Yong-Xin, AN Qi, YAO Zhi-Hui, HE Hao, SHU Zhi-Yong. Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3 .VIROLOGICA SINICA, 1991, 6(3) : 271.

一株广谱中和抗原性出血热病毒株的发现

1.
中国药品生物制品检定所
2.
安徽医学科学研究所
3.
浙江省卫生防疫站北京

摘要

一株分离自杭州市褐家鼠的出血热病毒Gou_3株的免疫血清对10株I型病毒的中和滴度除二株为160外均为320,而对4株Ⅱ型病毒的滴度为320—640,说明Gou_3株免疫血清对两型毒株中和效价大多数无差异或只差2倍,是一株中和抗原广谱的毒株。用I型和Ⅱ型毒株免疫血清对Gou_3株进行型别检定结果表明Gou_3株是Ⅱ型病毒。
- 流行性出血热病毒株
- , 中和抗原
- , 空斑减少
- , 中和试验

Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3

1.
National Institute for the Control of Pharmaceutical and Biological Products
2.
Beijing
3.
100050Anhui Institute of Medical Science

Abstract

Antigenicity of a HFRS virus strain, Gou_3, isolated from Rattus norvegicus, was studied by plaque reduction neutralization test. Anti-Gou_3 rabbit serum was used for neutralization with ten Type 1 HFRS viruses and_4 Type 2 viruses. The results revealed that anti-Gou_3 serum reacted to almost the same of neutralizing titer with most of the virus strains in both types, indicating that Gou_3 is a neutralizing antigen broad virus strain. This is the first discovery and it is of significance in selection of see...
- Hemrrhagic Fever with Renal Syndrome
- , Virus Neutralizing
- , antigen Plaque reduction neutralization test

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Discovery and Study of a Neutralizing Antigen Broad HFRS Virus Strain Gou3

1. National Institute for the Control of Pharmaceutical and Biological Products
2. Beijing
3. 100050Anhui Institute of Medical Science

Abstract: Antigenicity of a HFRS virus strain, Gou_3, isolated from Rattus norvegicus, was studied by plaque reduction neutralization test. Anti-Gou_3 rabbit serum was used for neutralization with ten Type 1 HFRS viruses and_4 Type 2 viruses. The results revealed that anti-Gou_3 serum reacted to almost the same of neutralizing titer with most of the virus strains in both types, indicating that Gou_3 is a neutralizing antigen broad virus strain. This is the first discovery and it is of significance in selection of see...