The Function of Poliovirus 2A Proteinase in the Polio-Vaccinia Recombinant Virus

LI Qi-Han; DAI Chang-Bai; YUAN Tian-Xi; HU Ning-Zhu; SU Ye; GUO Ren; HOU Yun-De; DAO Ying-Shuang

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February 1992

LI Qi-Han, DAI Chang-Bai, YUAN Tian-Xi, HU Ning-Zhu, SU Ye, GUO Ren, HOU Yun-De and DAO Ying-Shuang. The Function of Poliovirus 2A Proteinase in the Polio-Vaccinia Recombinant Virus[J]. Virologica Sinica, 1992, 7(1).

Citation: LI Qi-Han, DAI Chang-Bai, YUAN Tian-Xi, HU Ning-Zhu, SU Ye, GUO Ren, HOU Yun-De, DAO Ying-Shuang. The Function of Poliovirus 2A Proteinase in the Polio-Vaccinia Recombinant Virus .VIROLOGICA SINICA, 1992, 7(1) : 43.

脊髓灰质炎病毒2A蛋白在重组病毒中的功能研究

1.
中国医学科学院医学生物学研究所
2.
中国预防医学科学院病毒学研究所
3.
中国医学科学院医学生物学研究所昆明

摘要

应用所构建的不同脊髓灰质炎病毒-痘苗病毒(下简称PV-VV)重组体,探讨脊髓灰质炎病毒(下简称PV)2A蛋白在重组病毒中的作用。所得到的四个以不同PV基因片段插入痘苗病毒(下简称VV)TK区而形成的重组病毒均有PV抗原的表达,并可诱导抗体产生,但此表达水平明显受到2A蛋白的影响。同时,重组病毒对不同细胞的适应性亦有变化。对此,本文进行了初步的探讨。
- 重组病毒
- , 脊髓灰质炎病毒2A蛋白
- , 痘苗病毒

The Function of Poliovirus 2A Proteinase in the Polio-Vaccinia Recombinant Virus

1.
Institute of Medical Biology
2.
Chinese Academy of Medical Sciences
3.
Kunming 650107

Abstract

For studying the function of Poliovirus 2A proteinaes in Polio-Vaccinarecombinant virus, We constructed the various chimeric virus of Polio-Vac-cinia, and obtained 4 Polio--Vaccinia recombinant viruses which contain var-ious fragments of Polio virus I type mahoney strain gene. These fragmentswere inserted into the TK region of vaccinia gene. The antigen of Polioviruswas expressed in these 4 recombinant viruses, the antibody against Poliovirusl type was induced in the rabbit infected by these chimeric viruse...
- Recombinanl virus
- , Poliovirus 2A proteinase
- , Vaccinia virus

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Function of Poliovirus 2A Proteinase in the Polio-Vaccinia Recombinant Virus

1. Institute of Medical Biology
2. Chinese Academy of Medical Sciences
3. Kunming 650107

Abstract: For studying the function of Poliovirus 2A proteinaes in Polio-Vaccinarecombinant virus, We constructed the various chimeric virus of Polio-Vac-cinia, and obtained 4 Polio--Vaccinia recombinant viruses which contain var-ious fragments of Polio virus I type mahoney strain gene. These fragmentswere inserted into the TK region of vaccinia gene. The antigen of Polioviruswas expressed in these 4 recombinant viruses, the antibody against Poliovirusl type was induced in the rabbit infected by these chimeric viruse...