Effect of Astragalus Membranaceus on T Lymphocyte Mediated Immunity in Mice with Coxsackie B3 Viral Myocarditis

WU Wei-Zhong; YANG Ying-Zhen; JIN Pei-Ying

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April 1992

WU Wei-Zhong, YANG Ying-Zhen and JIN Pei-Ying. Effect of Astragalus Membranaceus on T Lymphocyte Mediated Immunity in Mice with Coxsackie B3 Viral Myocarditis[J]. Virologica Sinica, 1992, 7(2).

Citation: WU Wei-Zhong, YANG Ying-Zhen, JIN Pei-Ying. Effect of Astragalus Membranaceus on T Lymphocyte Mediated Immunity in Mice with Coxsackie B3 Viral Myocarditis .VIROLOGICA SINICA, 1992, 7(2) : 129.

黄芪对BALB/C小鼠感染Coxsackie B_3病毒后T细胞免疫的影响

1.
上海医科大学中山医院上海市心血管病研究所
2.
上海医科大学中山医院上海市心血管病研究所上海

摘要

本文用抗原特异性细胞毒技术检测小鼠感染coxsackie B_3病毒后并腹腔注射黄芪一周在5—28天脾脏、外周血及心肌中T淋巴细胞亚群分布的变化情况。结果显示:黄芪治疗组小鼠外周血、脾脏中Thy1+细胞百分率在感染后第7—14天明显增高(P<0.05),在心肌中则低于同期生理盐水组。L3T4+淋巴细胞百分率黄芪治疗组在病毒感染后5—14天的脾脏,第9天的外周血和第7、14天的心肌中显著低于生理盐水组,而Lyt2+淋巴细胞百分率两实验组间均无统计学差异,提示中药黄芪对急性病毒性心肌炎小鼠T细胞免疫具有明显的调节作用,且主要是通过调节Thy1+和L3T4+淋巴细胞亚群而起到治疗目的的。
- Coxsaekie C_3病毒
- , 急性病毒性心肌炎
- , 黄芪
- , Thyl+淋巴细胞
- , Lyt2+淋巴细胞
- , L3T4+淋巴细胞

Effect of Astragalus Membranaceus on T Lymphocyte Mediated Immunity in Mice with Coxsackie B3 Viral Myocarditis

1.
Shanghai Institute of Cardiovascular Disease
2.
Zhongshan Hospital

Abstract

Effect of Astragalus Membranaceus(AM) in lymphocyte subsets in an animal model of viral myocarditis were investigated by antigen specific cytotoxicity assay, The percentage of Thyl+cell in the peripheral blood and spleen was significantly higher in AM treated mice than in normal saline(NS) treated mice on 7th, 9th, 14th day(P<0.05) after Coxsackie B3 viral(CB 3V) inoculation, while it was statistically lower in myocardium in AM treated mice on 14th day after infection The percentage of L3T4+cell was mark...
- Coxsaekie B3 virus Acute viral myoearditis Astragalus Membranaceus Thyl+lymphocyte（pan-T） Lyt2+lymphocyte（Tc/s） L3T4+lymphocyte（Th/i）

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Effect of Astragalus Membranaceus on T Lymphocyte Mediated Immunity in Mice with Coxsackie B3 Viral Myocarditis

1. Shanghai Institute of Cardiovascular Disease
2. Zhongshan Hospital

Abstract: Effect of Astragalus Membranaceus(AM) in lymphocyte subsets in an animal model of viral myocarditis were investigated by antigen specific cytotoxicity assay, The percentage of Thyl+cell in the peripheral blood and spleen was significantly higher in AM treated mice than in normal saline(NS) treated mice on 7th, 9th, 14th day(P<0.05) after Coxsackie B3 viral(CB 3V) inoculation, while it was statistically lower in myocardium in AM treated mice on 14th day after infection The percentage of L3T4+cell was mark...