An Experimental Animal Model Study on Infection and Pathogensis of HCMV-AD_(169) Strain

GAO You-Xin; LIU Jian-Jun; YANG Tie-Qiu; TAO Hua-Jun; CENG Qiang-Bin; BANG Qian

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June 1993

GAO You-Xin, LIU Jian-Jun, YANG Tie-Qiu, TAO Hua-Jun, CENG Qiang-Bin and BANG Qian. An Experimental Animal Model Study on Infection and Pathogensis of HCMV-AD_(169) Strain[J]. Virologica Sinica, 1993, 8(3): 290-292.

Citation: GAO You-Xin, LIU Jian-Jun, YANG Tie-Qiu, TAO Hua-Jun, CENG Qiang-Bin, BANG Qian. An Experimental Animal Model Study on Infection and Pathogensis of HCMV-AD_(169) Strain .VIROLOGICA SINICA, 1993, 8(3) : 290-292.

人巨细胞病毒AD_(169)株感染家兔致病机理的初步研究

1.
湖北医学院病毒研究所
2.
湖北医学院附属第二医院
3.
湖北医学院附属第二医院武汉
4.
0071

摘要

本文试用家兔作HCMV感染致病机制模型研究,用家兔荧光法及病毒再分离技术考证了感染期间的病毒血症动态。观察到兔在原发性病毒感染后的第13无病毒首先在单核细胞(MC)、淋巴细胞(LC)中显现,并向血浆排放病毒,进而随血道播散至全身组织,引起相应靶器官感染致病。
- 人巨细胞病毒
- , 动物模型

An Experimental Animal Model Study on Infection and Pathogensis of HCMV-AD_(169) Strain

1.
Institute of Virology Hubei Medical College
2.
Wuhan
3.
0071
4.
0071

Abstract

This paper is a study on the result of animal model with HCMV. Rabbits were inoculated with HCMV-AD_(169) strain. The duration of viremic stage of rabbits infected with HCMV was studied by means of immunoflourescent assays and reisolation of the virus. Specific flourescence for HCMV anti- gen was first observed in both monocytes and lymphocytes in the blood on 13th day,and released the virus to the plasma. It was indicated that HCMV was disseminated to rabbits body, thus caused target or- gans infection.
- HCMV-AD（169）
- , Animal model

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

An Experimental Animal Model Study on Infection and Pathogensis of HCMV-AD_(169) Strain

1. Institute of Virology Hubei Medical College
2. Wuhan
3. 0071
4. 0071

Abstract: This paper is a study on the result of animal model with HCMV. Rabbits were inoculated with HCMV-AD_(169) strain. The duration of viremic stage of rabbits infected with HCMV was studied by means of immunoflourescent assays and reisolation of the virus. Specific flourescence for HCMV anti- gen was first observed in both monocytes and lymphocytes in the blood on 13th day,and released the virus to the plasma. It was indicated that HCMV was disseminated to rabbits body, thus caused target or- gans infection.