Observation of Pathological and Viral Antigen of
Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice

GUO Guang-Song; XIAO Hong; CHENG Li; WEN Li; YANG Zhan-Qiu

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February 1994

GUO Guang-Song, XIAO Hong, CHENG Li, WEN Li and YANG Zhan-Qiu. Observation of Pathological and Viral Antigen ofEpidemic-Hemorrhagic Fever Virus Infection in Suckling Mice[J]. Virologica Sinica, 1994, 9(1).

Citation: GUO Guang-Song, XIAO Hong, CHENG Li, WEN Li, YANG Zhan-Qiu. Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice .VIROLOGICA SINICA, 1994, 9(1) : 81.

流行性出血热病毒感染乳小白鼠的病理组织学与病毒抗原定位研究

1.
湖北医科大学病理学教研室湖北医科大学病毒研究所

摘要

Huggins(1986年)等观察了来自黑线蛭鼠的病毒(76—118株)感染乳小白鼠的病理组织学变化及病毒在脑组织中的分布,本实验观察了来自流行性出血热患者的EHFV对感染乳小白鼠的组织病理学变化和病毒抗原定位分布，现报告如下；
- 病毒抗原流行性出血热乳小白鼠病理变化

Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice

1.
Hubei Medical University

Abstract

Epidemic hemorrhagic fever virus origined from patients with epidemic hemorrhagic fever was inoculated into suckling mice,The results showed that the suckling mice died regularly,The viral antigenand pathological damage appeared in the brain,lung,liver and kidney,The characterization of patho-logical changes were congestion, hemorrhage and degeneration of blood vessels.The viral perticles canbe found in hippocampus region,The viral antigen can be detected in cytoplasm.The resultS suggestthat suckling mice were susceptible for human original epidemic hemorrhagic fever virus.
- Virai antigen Epidetmc hemorrtiagic fever Suckling mice Pathological damage

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Observation of Pathological and Viral Antigen of Epidemic-Hemorrhagic Fever Virus Infection in Suckling Mice

1. Hubei Medical University

Abstract: Epidemic hemorrhagic fever virus origined from patients with epidemic hemorrhagic fever was inoculated into suckling mice,The results showed that the suckling mice died regularly,The viral antigenand pathological damage appeared in the brain,lung,liver and kidney,The characterization of patho-logical changes were congestion, hemorrhage and degeneration of blood vessels.The viral perticles canbe found in hippocampus region,The viral antigen can be detected in cytoplasm.The resultS suggestthat suckling mice were susceptible for human original epidemic hemorrhagic fever virus.