本文以核酸原位分子杂交法研究了国内不同地区ＨＦＲＳ尸检病例组织中病毒ＲＮＡ的分布和定位。结果在１９例病例组织中均可检测到病毒ＲＮＡ。陕西及沈阳地区病例，阳性部位主要是各脏器上皮及实质细胞。江西地区病例，病毒ＲＮＡ主要出现于各脏器组织内血管壁及毛细血管内皮细胞。广州一例，病毒ＲＮＡ主要分布于肝脏灶性溶解性坏死区域，肺泡壁和肾间质血管等部位。病毒ＲＮＡ主要定位于细胞胞浆，呈颗粒状或全浆阳性，也出现干部分组织少数细胞胞核中。此外，病毒ＲＮＡ还出现于细胞外液和红细胞表面。结果说明，ＨＦＲＳ病毒具有泛嗜性感染及上皮性组织或血管内皮细胞易感的特点，后者可能取决于不同地区ＨＦＲＳ病例所感染的病毒的血清型或毒株不同，从而引起不同类型ＨＦＲＳ及其病理和发病机理的差异。

In situ hybridization was used for detection of hantavirus RNA in the tissues of 1 9 cadavers with hemorrhagic fever w ith renal syndrome (HFRS) collected from different HFRS endemic foei in China． Viral RNA wiLq detec ted in a11 the 1 9 cases． It was mainly located in epithelial or parenchymal ca lls of various organs with the positive cells in scattered，focal or wide distribution in the eases from Shaanxi and Shenyang，and in vascular endothelial cells of various organs as well as part of pa renchy real cells in the cases from Jiangxi，while in the case from Guangzhou．it was positive in focal necrotihe，alveolar sa ，renal interstit~l va u1a【urcs，etc．V RNA mainly I．oc,~liz．oci in the cytoplasms with ‰ rse grarlales orfine powdery specking staining．to a lesser extent also over cellular nucleus~ Besides．the po r,itive hybridization signals were also demonstrated in extrace linlar space~and oil RBC in some tissues and cases．The results suggest that hantavirus infection in human wz~ls ImntroDic and pred ilec tion for epithelial or endothelial cells an d th e latter may be caused by the difference of strain or scrotype of mfec ted virus，and may result to the variance in nathogenesis of HFRs．