ZHANG Ran, DONG Ji-Hua and TIAN Mu-Zhen. Antigenic variation of respiratory suncytical virus isolated in Wuhan from 1988 to 1992[J]. Virologica Sinica, 1995, 10(3).
Citation: ZHANG Ran, DONG Ji-Hua, TIAN Mu-Zhen. Antigenic variation of respiratory suncytical virus isolated in Wuhan from 1988 to 1992 .VIROLOGICA SINICA, 1995, 10(3) : 185.

武汉地区1988—1992年呼吸道合胞病毒流行株的抗原性分析

  • 利用呼吸道合胞病毒(RSV)的单克隆抗体(McAb),通过间接免疫荧光法和免疫转印法对本室分离到的武汉地区1988一1992年的56份RSV毒株进行了分型,可将其分为A、B两型和B1、B2亚型。流行病学分析显示:本地区RSV的主要流行株,四年中有三年为B型株,不同于欧美等地;A、B两型的分布还具有局灶化分布的特点;两型在性别、发病年龄之间无显著性差异。

Antigenic variation of respiratory suncytical virus isolated in Wuhan from 1988 to 1992

  • Indirect immunofluorescense and Western-blot methods with seven home-made McAbs against RSV were used to distinguish RSV strains isolated in Wuhan from 1 988 to 1 992.These strains were distinguished as type A and B,further as subgruup B_1 and B_2.The RSV epidemic patterns in Wuhan were different from those of Europe and America,but were simi-lar to those of Japan.The prevalence of the two types even varied in two districts of Wuhan in the same year.It suggests the that RSV outbreaks should be regional and temporal clust-ing. No major differences in age and sex were found between the infants and young children infected with either type.

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    Antigenic variation of respiratory suncytical virus isolated in Wuhan from 1988 to 1992

    • 1. Tongji Medical University

    Abstract: Indirect immunofluorescense and Western-blot methods with seven home-made McAbs against RSV were used to distinguish RSV strains isolated in Wuhan from 1 988 to 1 992.These strains were distinguished as type A and B,further as subgruup B_1 and B_2.The RSV epidemic patterns in Wuhan were different from those of Europe and America,but were simi-lar to those of Japan.The prevalence of the two types even varied in two districts of Wuhan in the same year.It suggests the that RSV outbreaks should be regional and temporal clust-ing. No major differences in age and sex were found between the infants and young children infected with either type.

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