YANG Dong-Liang, LI Lin, WANG You-Kun, CHEN Yue and HAO Lian-Jie. The significance of viral antigen and immune complexes in skin tissues of patients with epidemic hemorrhagic fever[J]. Virologica Sinica, 1995, 10(3).
Citation: YANG Dong-Liang, LI Lin, WANG You-Kun, CHEN Yue, HAO Lian-Jie. The significance of viral antigen and immune complexes in skin tissues of patients with epidemic hemorrhagic fever .VIROLOGICA SINICA, 1995, 10(3) : 221.

流行性出血热患者皮肤组织内病毒抗原及免疫复合物检测与意义

  • 应用常规病理、免疫病理及超微病理技术,对33例流行性出血热(EHF)患者皮肤活检标本的病理变化及病毒抗原、免疫复合物进行观察,同时与血清病毒抗原、抗体及循环免疫复合物检出情况进行比较。在23例EHF患者皮肤微血管内皮细胞中检出病毒抗原,部分组织中可同时检出免疫球蛋白及C3,少数组织仅能检出病毒抗原或免疫球蛋白。配对血清小也可检出EHF病毒抗原、抗体及循环免疫复合物。组织及血清免疫复合物形成与血清补体C3水平下降有关,组织内肥大细胞脱颗粒与血清IgE水平升高相关,提示多种变态反应参与了流行性出血热的发病机制。

The significance of viral antigen and immune complexes in skin tissues of patients with epidemic hemorrhagic fever

  • he techniques of pathology.immunohistochemistry and ultrastructural pathology were empluyed to study the pathological changes,specific virus antigens and immune complexes in the biopsy skin tissues of 33 cases of patients with epidemic hemorrhagic fever.The specific antigens,antibodies and circulatilng immune complexes in sera of the patients were also de-tected. T he specific viral antigens were detected in 23 skin samples of the patients and im-munoglobulins,complement component C_3 were also detected in some of the samples. How-ever,for a few samples,only the virus antigens or immunoglubulins were detected.The viral antigens,antibodies and immune complexes appeared in the sera of the patients showed some relationship with the severity and the phase of illness,Furthermore,we found that there were correlations between the consumption of C_3 and the formation of immune complexes,also the degranulation of dermal mast cells and the elevation of immunoglobulin E level in sera of the patients.These suggest

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    The significance of viral antigen and immune complexes in skin tissues of patients with epidemic hemorrhagic fever

    • 1. Clinical Immunology Research Unit,Tongji Hospital,Tongji Medical University,Wuhan 430030

    Abstract: he techniques of pathology.immunohistochemistry and ultrastructural pathology were empluyed to study the pathological changes,specific virus antigens and immune complexes in the biopsy skin tissues of 33 cases of patients with epidemic hemorrhagic fever.The specific antigens,antibodies and circulatilng immune complexes in sera of the patients were also de-tected. T he specific viral antigens were detected in 23 skin samples of the patients and im-munoglobulins,complement component C_3 were also detected in some of the samples. How-ever,for a few samples,only the virus antigens or immunoglubulins were detected.The viral antigens,antibodies and immune complexes appeared in the sera of the patients showed some relationship with the severity and the phase of illness,Furthermore,we found that there were correlations between the consumption of C_3 and the formation of immune complexes,also the degranulation of dermal mast cells and the elevation of immunoglobulin E level in sera of the patients.These suggest

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