Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb
in Oral for EHFV Infection in Suckling Mice

XIAO Hong; YANG Zhan-Qiu; WEN Li; LIU Yan-Wen

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August 1996

XIAO Hong, YANG Zhan-Qiu, WEN Li and LIU Yan-Wen. Pharm acodynam ics Studies of Alternanthera philoxeroides Grisebin Oral for EHFV Infection in Suckling Mice[J]. Virologica Sinica, 1996, 11(4).

Citation: XIAO Hong, YANG Zhan-Qiu, WEN Li, LIU Yan-Wen. Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice .VIROLOGICA SINICA, 1996, 11(4) : 348.

空心莲子草口服治疗乳鼠流行性出血热病毒感染的研究

1.
湖北医科大学病毒研究所湖北中医学院

摘要

空心莲子草经口服治疗流行性出血热病毒（ＥＨＦＶ）感染的乳鼠。结果显示，５、７．５、１０．０ｍｇ三个剂量组的存活率各为８０％、７２．２％和４０．０％，平均存活天数（ＭＴＤ）为５６．５±０．９、５３．５±１．１和４１．５±２．７ｄ，而病毒对照组的存活率为０．０％，ＭＴＤ为２６．３±０．８ｄ，经该药治疗的感染鼠体内的ＥＨＦＶ抗原表达减少，而未经治疗的感染乳鼠体内的ＥＨＦＶ抗原则在全病程中都显示出较强的表述。治疗组抗病毒效果类似于病毒唑，且口服病毒唑毒性小。说明空心莲子草在体内对ＥＨＦＶ感染鼠有治疗作用。
- 出血热病毒乳鼠空心莲子草

Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice

1.
Virus Research Institute，Hubei Medical University，Wuhan 430071Hubei Traditional Medical College．Wuhan 430060

Abstract

Antiviral effect of Alternanthera philoxeroides Griseb(APG)was studied in oral for epi-demic hemorrhagic fever virus(EHFV)infection in suckling mice.The APG dosages of A,BandC groups were 5mg/(g·d),7.5mg/(g·d)and 10mg/(g·d),respectively. The results showedthat the survival rate of A,B and C group were 80.0%,72.2% and 40.0%,the means time day(MTD)were 56.5±0.9, 53.5±1.1 and 41.5±2.7 day,respectively.The survival rate and MTD were 0.0% and 26.3±0.8 day in untreated viral control group.The antiviral effect of theAPG was similar with the ribavirin.This indicated that the APG was effective in treatment of epidemic hemorrhagic fever.
- Hantanvirus Alternanthera philoxeroides Griseb Sucking mice

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Pharm acodynam ics Studies of Alternanthera philoxeroides Griseb in Oral for EHFV Infection in Suckling Mice

1. Virus Research Institute，Hubei Medical University，Wuhan 430071Hubei Traditional Medical College．Wuhan 430060

Abstract: Antiviral effect of Alternanthera philoxeroides Griseb(APG)was studied in oral for epi-demic hemorrhagic fever virus(EHFV)infection in suckling mice.The APG dosages of A,BandC groups were 5mg/(g·d),7.5mg/(g·d)and 10mg/(g·d),respectively. The results showedthat the survival rate of A,B and C group were 80.0%,72.2% and 40.0%,the means time day(MTD)were 56.5±0.9, 53.5±1.1 and 41.5±2.7 day,respectively.The survival rate and MTD were 0.0% and 26.3±0.8 day in untreated viral control group.The antiviral effect of theAPG was similar with the ribavirin.This indicated that the APG was effective in treatment of epidemic hemorrhagic fever.