GONG Zhen-Kui, HUANG He, JIA Lin and XIAO Hong-Yu. Early Diagnosis of Rubella Virus Infection with Monoclonal Antibodyagainst Human IgM (u Chain)[J]. Virologica Sinica, 1997, 12(3).
Citation: GONG Zhen-Kui, HUANG He, JIA Lin, XIAO Hong-Yu. Early Diagnosis of Rubella Virus Infection with Monoclonal Antibody against Human IgM (u Chain) .VIROLOGICA SINICA, 1997, 12(3) : 281.

用抗人IgM(μ链)单克隆抗体早期诊断风疹病毒感染

  • 风疹病毒(Rubella virus)感染引起风疹.该病一般症状较轻.有的甚至不出现明显症状.预 后良好。但孕妇受感后。病毒可经血液通过胎盘感染胎儿.除引起流产、早产或死胎外.活产者 大约有20%表现先天性风疹综合症.导致先天畸形? 。因此.对风疹病毒感染的早期诊断与 优生优育、提高出生人口素质有极为重要的关系。本研究用抗人IgM(p链)单克隆抗体 (McAb)作标记抗体,采用间接ELISA检测血清中抗风疹病毒特异性IgM 抗体.进行早期诊 断。结果报道如下。

Early Diagnosis of Rubella Virus Infection with Monoclonal Antibody against Human IgM (u Chain)

  • An indirect ELISA by using monoclonal antibody (McAb) against hutnan IgM (μ chain)as the antibody labeled with horseradish peroxidase (second antibody) is used in detecion Rubela virus - specific IgM for early diagnosis of Rubella virus infection. Through the detection and verifition of a large number of sera from normal population, the population closely contacted with Rubella virus and IgM - positive sera samples of Measles virus, cycoegaforirm and Toxplasma Gondii, it is indicated that this method is specific, seusiuive, simple, rapid and no cross - reaction with the positive sera of the pathogens menticned above, It can be used for early diagnosis of Rubella virus infection and epidemiological survey.

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    Early Diagnosis of Rubella Virus Infection with Monoclonal Antibody against Human IgM (u Chain)

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    Abstract: An indirect ELISA by using monoclonal antibody (McAb) against hutnan IgM (μ chain)as the antibody labeled with horseradish peroxidase (second antibody) is used in detecion Rubela virus - specific IgM for early diagnosis of Rubella virus infection. Through the detection and verifition of a large number of sera from normal population, the population closely contacted with Rubella virus and IgM - positive sera samples of Measles virus, cycoegaforirm and Toxplasma Gondii, it is indicated that this method is specific, seusiuive, simple, rapid and no cross - reaction with the positive sera of the pathogens menticned above, It can be used for early diagnosis of Rubella virus infection and epidemiological survey.

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