The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro

WU Ting; HUANG Hai

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February 1998

WU Ting and HUANG Hai. The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro[J]. Virologica Sinica, 1998, 13(1).

Citation: WU Ting, HUANG Hai. The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro .VIROLOGICA SINICA, 1998, 13(1) : 45.

恩拉霉素抗乙型肝炎病毒的体外实验研究

吴婷 ,
黄海

1.
上海医科大学药学院

摘要

以ＨｅｐＧ２．２．２．１５细胞株为模型，以其分泌的ＨＢｓＡｇ、ＨＢｅＡｇ、ＨＢＶＤＮＡ及细胞存活率为观察指标，综合评价天然多肽类抗生素恩拉霉素体外抗ＨＢＶ效果。结果表明恩拉霉素对ＨＢｓＡｇ和ＨＢｅＡｇ的５０％抑制浓度ＩＣ５０分别为２７μｇ／ｍＬ和３４μｇ／ｍＬ，治疗指数（ＴＩ）分别为５．９和４．６。Ｓｏｕｔｈｅｒｎ结果显示，５０μｇ／ｍＬ恩拉霉素对细胞内游离ＨＢＶＤＮＡ抑制率为５６．８％。
- 恩拉霉素抗乙肝病毒多肽类抗生素

The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro

WU Ting ,
HUANG Hai

1.
School of Pharmacy，Shanghai Medical Universlty，Shanghai 200032

Abstract

Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG 2.2.2.15). The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.
- Enduracidin Anti HBV Polypeptide antibiotics

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Inhibitory Effects of Enduracidin on Hepatitis B Virus in vitro

WU Ting ,
HUANG Hai

1. School of Pharmacy，Shanghai Medical Universlty，Shanghai 200032

Abstract: Enduracidin was studied for its ability to inhibit Hepatitis B Virus DNA, HBsAg and HBeAg secreted by a HBV transfected cell line (HepG 2.2.2.15). The result showed that IC 50 (the drug concentration that inhibits HBsAg or HBeAg secretion by 50%)was 27μg/mL and 34μg/mL respectively, theraputic index (TI) was 5.9 and 4.6. Enduracidin at the concentration of 50μg/mL inhibited 56.8% of the production of free HBV DNA in the Cells.