XIE Lin, YANG Shou-Jing, LIU Yan-Fang and YAN Pei-Song. Localization and distribution of HSP70 mRNA and Hantann virus in autopsytissue of the patients with EHF and in virus-infected cells[J]. Virologica Sinica, 1998, 13(4).
Citation: XIE Lin, YANG Shou-Jing, LIU Yan-Fang, YAN Pei-Song. Localization and distribution of HSP70 mRNA and Hantann virus in autopsy tissue of the patients with EHF and in virus-infected cells .VIROLOGICA SINICA, 1998, 13(4) : 332.

流行性出血热尸检组织中热休克蛋白70mRNA的定位及分布

  • 应用核酸原位分子杂交技术研究了国内不同地区30例流行性出血热患者尸检组织中病毒RNA及HSP70mRNA细胞内定位,同时观察了汉坦病毒感染的VeroE6细胞中HSP70的表达情况。结果表明,热休克蛋白70mRNA在多数组织中均可检测到,分布与病毒RNA一致,并且与组织的病理损害有关;体外实验的结果也表明在出血热病毒感染的细胞中有HSP70的高表达。提示热休克蛋白与汉坦病毒的致病以及流行性出血热的发病机理有关。

Localization and distribution of HSP70 mRNA and Hantann virus in autopsy tissue of the patients with EHF and in virus-infected cells

  • With in situ hybridization technique the localization and distribution of HSP70 mRNA and Hantaan virus RNA in the tissues of 30 cadavers with epidemic hemorrhagic fever (EHF), which were collected from different EHF epidemic foci in China, were examined. HSP70 mRNA was detected in most of the 30 cases and consistent with the localization and distribution of viral RNA.The distribution of HSP70 mRNA was partly related with the pathogenesis of HFRS. The over expression of HSP70 was also found in the virus infected Vero E 6 cells. It suggested that HSP was associated with the infection of Hantaan virus.

  • 加载中
  • 加载中

Article Metrics

Article views(3771) PDF downloads(849) Cited by(0)

Related
Proportional views
    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Localization and distribution of HSP70 mRNA and Hantann virus in autopsy tissue of the patients with EHF and in virus-infected cells

    • 1. 

    Abstract: With in situ hybridization technique the localization and distribution of HSP70 mRNA and Hantaan virus RNA in the tissues of 30 cadavers with epidemic hemorrhagic fever (EHF), which were collected from different EHF epidemic foci in China, were examined. HSP70 mRNA was detected in most of the 30 cases and consistent with the localization and distribution of viral RNA.The distribution of HSP70 mRNA was partly related with the pathogenesis of HFRS. The over expression of HSP70 was also found in the virus infected Vero E 6 cells. It suggested that HSP was associated with the infection of Hantaan virus.

    Relative (20)

    目录

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return