Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures

BANG Guang-Yong; TAO Kun; LIN Jiang; JI Xiao-Hui

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August 1999

BANG Guang-Yong, TAO Kun, LIN Jiang and JI Xiao-Hui. Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures[J]. Virologica Sinica, 1999, 14(4): 328-332.

Citation: BANG Guang-Yong, TAO Kun, LIN Jiang, JI Xiao-Hui. Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures .VIROLOGICA SINICA, 1999, 14(4) : 328-332.

人类疱疹病毒7型感染脐血单个核细胞产生TNF-

1.
南京医科大学微生物教研室，南京210029

摘要

用生物活性法，检测人类疱疹病毒7型Glasgow株和南京地方株YY5及HHV-6GS株感染单个核细胞培养上清中肿瘤坏死因子－（TNF-）的水平。结果发现，HHV-7对也能较强地诱生TNF-，但达到峰值时间（3～4d）迟于HHV-6GS株（2d）；在感染24h上请中，GS株产生TNF-量明显多于YY5株、Glasgow株产生量（P＜0．05），三者与未感染单个核细胞比较都存在显著差异（P＜0．05），但Glasgow珠和YY5株之间无差异（P＞0．05）。结果表明，HHV-6、HHV-7都能通过刺激单个核细胞产生TNF-而发挥免疫调节功能。
- 人类疱疹病毒6型（HHV-6）
- , 人类疱疹病毒7型（HHV-7）
- , 肿瘤坏死因子- 病毒感染

Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures

1.
Department of Microbiology，Nanjing Medical University，Nanjing 210029

Abstract

The production of tumor necrosis factor alpha(TNF-a)induced by human herpesvims 7(HHV一7)G1asgow strain and Nanjing loca1 strain YY5 and HHV一6 GS strain in umbilica1 cord and pheripheraI blood mononuclear cells cultures was studied by means of biologicaI activity assay． It was observed that HHV．7 is another strong inducer of TNF．q． HHV．7．infected cultlJre~ reached the maximal1eveI of TNF．q at 3 to 4 days postinfetion。which is later than that of HHv_ 6(2 days postinfection)．Compared with HHv．6，the amounts of TNF．a in HHV一7一infected cul tures are smaller at 24 h postinfetion(P0．05)，but the amounts of them are alI higher than that of uninfected cells(P0．05)，and there is no diference between G1asgow and YY5 strain (P0．05)．These results indicated that HHV一6 and HHV一7 can exert immunomodulatory by stimulating the CBMCs to produce TNF-a。
- Human Herpesvirus 6
- , Human Herpesvirus 7
- , Tumor Necrosis Factor Alpha(TNFq)

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Human Herpesvirus 7 Induces Tumor Necrosis Factor Alpha in Umbilical Cord Blood M ononuclear Cell Cultures

1. Department of Microbiology，Nanjing Medical University，Nanjing 210029

Abstract: The production of tumor necrosis factor alpha(TNF-a)induced by human herpesvims 7(HHV一7)G1asgow strain and Nanjing loca1 strain YY5 and HHV一6 GS strain in umbilica1 cord and pheripheraI blood mononuclear cells cultures was studied by means of biologicaI activity assay． It was observed that HHV．7 is another strong inducer of TNF．q． HHV．7．infected cultlJre~ reached the maximal1eveI of TNF．q at 3 to 4 days postinfetion。which is later than that of HHv_ 6(2 days postinfection)．Compared with HHv．6，the amounts of TNF．a in HHV一7一infected cul tures are smaller at 24 h postinfetion(P0．05)，but the amounts of them are alI higher than that of uninfected cells(P0．05)，and there is no diference between G1asgow and YY5 strain (P0．05)．These results indicated that HHV一6 and HHV一7 can exert immunomodulatory by stimulating the CBMCs to produce TNF-a。