M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

HUANG Ping; SHEN Gui—zhang; NI Han—zhong; ZHOU Hui-qiong

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February 2001

HUANG Ping, SHEN Gui—zhang, NI Han—zhong and ZHOU Hui-qiong. M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996[J]. Virologica Sinica, 2001, 16(1): 1-6.

Citation: HUANG Ping, SHEN Gui—zhang, NI Han—zhong, ZHOU Hui-qiong. M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996 .VIROLOGICA SINICA, 2001, 16(1) : 1-6.

广东地区1996年流感暴发的分子变异基础

1.
广东省疾病预防控制中心．原广东省卫生防痤站，广东广州市510300

摘要

1996年广东地区流感毒株发生明显的血清学抗原漂移；引起广东地区流感暴发的分子基础是流感毒株HA 基因编码的A、B、C、D和E五个抗原决定簇位点变异．尤其是A、c、E位点发生氨基酶改变；而受体位点的氨基酸改变对此流感流行未发挥明显影响。HA基因编码氪基酸的第145号和第193号位点变异导致流行毒株的生物学特性改变，即分离株适应于MDCK细晦株生长。而难适应鸡胚生长环境。
- 流感病毒
- , 血凝素基因
- , 变异

M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

1.
Center for Desease Control and Prevention of Guangdong Province，Guangzhou 510300．China

Abstract

It was demonstrated that there vcas significantly antigenic drift in the influenza virus strains from Guangdong in 1996 I r was the mokcular basis of the variation oll A、B、C、D and E domain en— coded by HA gene，especially on A、C and E domain while the change of receptor binding domain played the slight roles in the 1996 influenza outbreak 1n the other hand．the variation of No 145 and No 193 encoded by klA gene resuked in biological—feature changes of epidemical influenzu iso~．ates． which could be iso[ated and cultured by MDCK cell—lines。but difficultly by embryonated．eggs
- Infiuenza Virus
- , HA Gene
- , Variation

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

M olecular Evolution of Guangdong Influenza Virus Isolates in Influenza Outbreak in 1996

1. Center for Desease Control and Prevention of Guangdong Province，Guangzhou 510300．China

Abstract: It was demonstrated that there vcas significantly antigenic drift in the influenza virus strains from Guangdong in 1996 I r was the mokcular basis of the variation oll A、B、C、D and E domain en— coded by HA gene，especially on A、C and E domain while the change of receptor binding domain played the slight roles in the 1996 influenza outbreak 1n the other hand．the variation of No 145 and No 193 encoded by klA gene resuked in biological—feature changes of epidemical influenzu iso~．ates． which could be iso[ated and cultured by MDCK cell—lines。but difficultly by embryonated．eggs