ZHANG Yi-bing and GUI Jian-fang. Studies Oil Interferon-inducible Mx Proteins in Fish[J]. Virologica Sinica, 2001, 16(4): 291-298.
Citation: ZHANG Yi-bing, GUI Jian-fang. Studies Oil Interferon-inducible Mx Proteins in Fish .VIROLOGICA SINICA, 2001, 16(4) : 291-298.

干扰素诱导的鱼类Mx蛋白

  • Mx蛋白是干扰紊诱导表达的蛋白家族中的成员,当机体和细胞受病毒感染或诱生荆处理时产生。 蛋白和 其它干扰素诱导蛋白一起构成宿主细胞的抗病毒状态,以达到抗病毒的目的。研究表明, 蛋白具有抗病毒活 性,还可能与其它基本生命活动如发育或分化,蛋白质分送和生长有关。在鱼类也发现多种Mx蛋白,具有Mi蛋白 家族的共有特征:在肽链末端有一个三联ATP/GTP结合区和发动蛋白家族的结构特征序列;在蛋白C端存在使Mx 蛋白形成三聚体的ku拉链结构以及定位信号。但是迄今没有发现龟类Mx蛋白的抗病毒活性。文章最后对目前 鱼类病毒病的防治及利用抗病毒基目进行鱼类基臣工程抗病毒育种进行了探讨。Mx proteins are members of a family of interferon inducible genes expressed in organisms or cells which are treated with all sorts of inducers or virus infection.These proteins together with other interferon inducible proteins form the antiviral state in host cells and the first line of the body’s defense against virus infection.Apart from the inhibtion of a specific virus,Mx proteins may be related with other basic cellular functions such as development/differentiation,protein sorting and growth.Mx proteins in several fishes are found and a comparsion of their sequences with that of avian and mammalian species reveals striking conservation of domains.They all maintain a tripartite ATP/GTP binding motif and a signature of the dynamin family in the amino terminal of the protein.In addition,the C terminal region of the Mx proteins contains the localization signals and the leucine zipper motif which account for the trimerization of Mx in the cell.So far,the antiviral function of the fish Mx proteins has not b

Studies Oil Interferon-inducible Mx Proteins in Fish

  • Mx proteins are members of a family of interferon inducible genes expressed in organisms or cells which are treated with all sorts of inducers or virus infection.These proteins together with other interferon inducible proteins form the antiviral state in host cells and the first line of the body’s defense against virus infection.Apart from the inhibtion of a specific virus,Mx proteins may be related with other basic cellular functions such as development/differentiation,protein sorting and growth.Mx proteins in several fishes are found and a comparsion of their sequences with that of avian and mammalian species reveals striking conservation of domains.They all maintain a tripartite ATP/GTP binding motif and a signature of the dynamin family in the amino terminal of the protein.In addition,the C terminal region of the Mx proteins contains the localization signals and the leucine zipper motif which account for the trimerization of Mx in the cell.So far,the antiviral function of the fish Mx proteins has not b

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    Studies Oil Interferon-inducible Mx Proteins in Fish

    • 1. Zhang Yi-bing,GUI Jian-fang

    Abstract: Mx proteins are members of a family of interferon inducible genes expressed in organisms or cells which are treated with all sorts of inducers or virus infection.These proteins together with other interferon inducible proteins form the antiviral state in host cells and the first line of the body’s defense against virus infection.Apart from the inhibtion of a specific virus,Mx proteins may be related with other basic cellular functions such as development/differentiation,protein sorting and growth.Mx proteins in several fishes are found and a comparsion of their sequences with that of avian and mammalian species reveals striking conservation of domains.They all maintain a tripartite ATP/GTP binding motif and a signature of the dynamin family in the amino terminal of the protein.In addition,the C terminal region of the Mx proteins contains the localization signals and the leucine zipper motif which account for the trimerization of Mx in the cell.So far,the antiviral function of the fish Mx proteins has not b

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