Experimental Studies and Comparison on Clinic Diagnosis of TORCH IgM Antibody

KUANG Er; YANG Fu-hua; HE Xiang-Wan; LIU Jian; YAN Yin

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February 2002

KUANG Er, YANG Fu-hua, HE Xiang-Wan, LIU Jian and YAN Yin. Experimental Studies and Comparison on Clinic Diagnosis of TORCH IgM Antibody[J]. Virologica Sinica, 2002, 17(1): 56-60.

Citation: KUANG Er, YANG Fu-hua, HE Xiang-Wan, LIU Jian, YAN Yin. Experimental Studies and Comparison on Clinic Diagnosis of TORCH IgM Antibody .VIROLOGICA SINICA, 2002, 17(1) : 56-60.

抗T0RcH．IgM 型抗体临床对比检测研究

1.
1．武汉大学生命科学学院，武汉430072
2.
湖北省医学检验研究中心，武汉430060
3.
汉大学医学院病毒学研究所，武汉430071

摘要

摘要：TORCH系列病原微生物(包括弓形虫Tox、风疹病毒RuV、巨细胞病毒CMV、单纯疱疹病毒HSV I／Ⅱ等) 是一组具有致畸作用的病原俸孕妇感染可导致流产、早产、畸形甚至死眙目前TORCH IgM型抗体的检误I都在不同程度上受到非特异性的干扰，采用有效方法消除干扰对TORCH IgM型抗体检测的准确性至关重要为此我们对比了多种消除IEM检测中非特异性干扰的方法．并以最佳方法对256倒女性献血者、143倒正常妊娠和61例异常妊娠标本进行ToRCH IgM抗体的对比检测。结果显示健康人群中TORCH活动性感染率较高，健康孕妇 TORCHIgM 的总阳性率高达23 1％(其中Tox5 6％、CMV9 8％、RuV8 4％、HSV4 9％)；而异常妊娠则显著上升 (p0 01)．其中Tox、CMV、RuVIgM 阳性率上升明显(P0 05)，分别为l9 7％、26 2％、24 6％。由此可见孕期 TORCH病原微生物活动感染是致异常妊娠的主要因素之一．应严密监视孕期TORCH病原檄生物活动性感染，特别是弓形虫、风疹病毒和巨细胞病毒的感染。
- TORCH
- , IgM

Experimental Studies and Comparison on Clinic Diagnosis of TORCH IgM Antibody

1.
1 College 0f life science．Wuhan University．Wuhan 430072，China
2.
provincial Research Center rMedicalLaborato— ries，Wuhan 430060，China
3.
Institute of Virology．College of Medicine，Wuhan University，Wuhan 430071，Ch ina

Abstract

Abstract：To research ToRCH IgM clinic diagnosis，four kinds for methods for non—specific interfer— enee removed have been compared in IgM detection；then ToRCH IgM in sera of 256 female donors． 143 normal pregnant women and 61 abnormal pregnant women were detected with the best method ． anti—human IgG( chain specific)，resolving non-specific interference The results show that the posi— tive late of T。RCH IgM in normal population was very high，it was up to 23 1％ in health pregnant women(Tox 5．6％．CMV9．8％．RuV8．4％，HSV4 9％ respectively)，while it increased dramatically in abnorm_al pregnantwomen(p0．01)．SO didTox，CMV．RuVIgM(9．7％，26．2％，24．6％ respec— tively)．Then T0RCH pathogen active infection during pregnancy can Cause abnorma l pregnancy and should be inspe cted carefully．esp．Tox，CMV，RuV．
- T0RCH
- , IgM

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Experimental Studies and Comparison on Clinic Diagnosis of TORCH IgM Antibody

1. 1 College 0f life science．Wuhan University．Wuhan 430072，China
2. provincial Research Center rMedicalLaborato— ries，Wuhan 430060，China
3. Institute of Virology．College of Medicine，Wuhan University，Wuhan 430071，Ch ina

Abstract: Abstract：To research ToRCH IgM clinic diagnosis，four kinds for methods for non—specific interfer— enee removed have been compared in IgM detection；then ToRCH IgM in sera of 256 female donors． 143 normal pregnant women and 61 abnormal pregnant women were detected with the best method ． anti—human IgG( chain specific)，resolving non-specific interference The results show that the posi— tive late of T。RCH IgM in normal population was very high，it was up to 23 1％ in health pregnant women(Tox 5．6％．CMV9．8％．RuV8．4％，HSV4 9％ respectively)，while it increased dramatically in abnorm_al pregnantwomen(p0．01)．SO didTox，CMV．RuVIgM(9．7％，26．2％，24．6％ respec— tively)．Then T0RCH pathogen active infection during pregnancy can Cause abnorma l pregnancy and should be inspe cted carefully．esp．Tox，CMV，RuV．