XIAO Chun—hui, YANG Zhan—qiu, XIAO Hong, XIONG Zeng-hui, W EN Li, HOU W ei and LIU Hong. Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro[J]. Virologica Sinica, 2002, 17(2): 102-105.
Citation: XIAO Chun—hui, YANG Zhan—qiu, XIAO Hong, XIONG Zeng-hui, W EN Li, HOU W ei, LIU Hong. Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro .VIROLOGICA SINICA, 2002, 17(2) : 102-105.

喷昔洛韦体外抗疱疹病毒活性的研究

  • 摘要:为评价新合成的喷昔洛韦的细胞毒性和抗疱疹病毒活性,通过观察病毒感染细胞的CPE、病毒滴度、抗病毒 指数,^L而判定喷昔洛韦的抗疱疹病毒作用。结果发现喷昔洛韦对HEL细胞、Hep-2细胞的半数中毒浓度(TDso) 分别为105.2tag/mL和85.1~g/mL;对HSV一1、HSV 2、VZV、HSV—i吴株的平均半数抑制浓度(I )分别为 21,78gg/mL、20 15gg/mL、23 19.ug/mL和17 87tag/mL.对各毒株的浩疗指数分别为5 84、6 31、5.49和7 n。 故喷昔洛韦是一种有效体外抗疱疹病毒药物。

Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro

  • In order to evaluate the cytotoxicity and antiherpesvlral activity of penciclovir,the antiher— pesvlral effect of PCV was investigated by observing eytopathie efect(CPE)and the change of viral infectious titre jn cells infected with herpesvirus,antiviral index and treatment index,The result shows the 50% toxicity dose(TD50)。f PCV to HEL ceil and Hep-2 ceil are 105.2txg/mL and 85.1~g/mL respectively;the average 50% inhibitory coneertration(IC50)of PCV to HSV一1,HSV一2,VZV.HSV一1 wU strain are 21 78fxg/mL,20 15~tg/mL,23.19~g/ml and 17,875g/mL respectively:teat index are 5 84,6 31.5,49 and 7 1 1 respectively.It is indicated that penciclovir is an effective anti—herpesvirus compound in vitro,

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    Research of Antiviral Activity of Pcnciclovir to Herpesvirus in vitro

    • 1. 1 The Institute of Virology theMedical School Wuhan University,Hubei Wuhan 430071
    • 2. Medicine Industry of Hubei Wuhan 430000.China

    Abstract: In order to evaluate the cytotoxicity and antiherpesvlral activity of penciclovir,the antiher— pesvlral effect of PCV was investigated by observing eytopathie efect(CPE)and the change of viral infectious titre jn cells infected with herpesvirus,antiviral index and treatment index,The result shows the 50% toxicity dose(TD50)。f PCV to HEL ceil and Hep-2 ceil are 105.2txg/mL and 85.1~g/mL respectively;the average 50% inhibitory coneertration(IC50)of PCV to HSV一1,HSV一2,VZV.HSV一1 wU strain are 21 78fxg/mL,20 15~tg/mL,23.19~g/ml and 17,875g/mL respectively:teat index are 5 84,6 31.5,49 and 7 1 1 respectively.It is indicated that penciclovir is an effective anti—herpesvirus compound in vitro,

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