Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

SUN Xiao; XIE Jian-ruing; ZHOU Shi-xin; XIE Xue-ying; LU Zu-hong

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August 2003

SUN Xiao, XIE Jian-ruing, ZHOU Shi-xin, XIE Xue-ying and LU Zu-hong. Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses[J]. Virologica Sinica, 2003, 18(4): 335-339.

Citation: SUN Xiao, XIE Jian-ruing, ZHOU Shi-xin, XIE Xue-ying, LU Zu-hong. Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses .VIROLOGICA SINICA, 2003, 18(4) : 335-339.

SARS病毒与其他冠状病毒的基因组比较

1.
东南大学生物科学与医学工程系，江苏南京，210096

摘要

摘要：本文利用生物信息学方法比较SARS病毒和其他冠状病毒基因组。通过数据库搜索，找出与SARS病毒基因组相似的核酸或蛋白质序列，并对相似序列进行比对，分析它们的共性和差异。结果表明，SARS病毒在基因组的组织上及结构蛋白质方面与现有冠状病毒有比较大的相似性，SARS病毒基因组与冠状病毒基因组相关。但是，SARS病毒基因组还存在一些特异性序列，ORFla和S蛋白(特别是S1)的变化以及SARS．CoV特异性的非结构蛋白可能是SARS 发病机理与传染特性区别于其他冠状病毒的分子基础。在全基因组水平上进行核酸单词出现频率分析，结果表明，SARS 病毒远离已知的其他冠状病毒，单独成为一类。
- SARS病毒(SARS．CoV)
- , 冠状病毒
- , 基因组学
- , 序列分析

Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

1.
Department ofBiological Science＆Medical Engineering，Southeast University,Nanfing 210096，China

Abstract

Abstract：The genome sequences of SARS．associated coronavirus (SARS．COV)were compared witIlother Coronaviruses．Similar sequences were found by searching biomolecular databases．Sequenceanalysis showed that SARS．CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses．SARS．CoV is related to other known Coronaviruses．But therewere some specific sequences in SARS．CoV genome．Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins．Th e result of wordfrequency an alysis indicated that SARS．CoV does not closely resemble an y of kn own Coronaviruses．
- Kev words：． RS．associated coronavirus(SARS．CoV)
- , Coronavirus
- , Genomics
- , Sequence Analysis

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Genome Comparison Between SARS—associated coronavirus andOther Coronaviruses

1. Department ofBiological Science＆Medical Engineering，Southeast University,Nanfing 210096，China

Abstract: Abstract：The genome sequences of SARS．associated coronavirus (SARS．COV)were compared witIlother Coronaviruses．Similar sequences were found by searching biomolecular databases．Sequenceanalysis showed that SARS．CoV had similar genomi c organization and structural proteins whilecompared with other Coronaviruses．SARS．CoV is related to other known Coronaviruses．But therewere some specific sequences in SARS．CoV genome．Th e virulence of SARS may deftve fromvaxi~ions of ORF l a an d S protein an d the specificity of some nonstructural proteins．Th e result of wordfrequency an alysis indicated that SARS．CoV does not closely resemble an y of kn own Coronaviruses．