Detection of HBV Mutation Associated with Lamivudine By Gene Chips

XU Yi-ying; REN Li-li

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August 2004

XU Yi-ying and REN Li-li. Detection of HBV Mutation Associated with Lamivudine By Gene Chips[J]. Virologica Sinica, 2004, 19(4): 410-412.

Citation: XU Yi-ying, REN Li-li. Detection of HBV Mutation Associated with Lamivudine By Gene Chips .VIROLOGICA SINICA, 2004, 19(4) : 410-412.

基因芯片技术检测拉美夫定相关的HBV变异

徐宜英* ^, ,
任莉莉

1.
深圳市人民医院临床医学研究中心深圳 518020

通讯作者： 徐宜英*, ;

摘要
- 基因芯片
- , 拉美夫定
- , 基因突变

Detection of HBV Mutation Associated with Lamivudine By Gene Chips

XU Yi-ying ^, ,
REN Li-li

1.
Clinical Research Center, Shenzhen People’s Hospital, Shenzhen 518020,China

Corresponding author: XU Yi-ying,

Abstract

In order to study the feasibility of gene chips technology in the detection of HBV mutation associated with lamivudine, we detected the mutation of HBV in peripheral blood of 30 patients treated with lamivudine for at least half a year by gene chips. The result was compared with that from direct sequencing. Both results are highly coincident. The rate reaches 100% while detecting single strain of virus infection, and 85% in multi-strains virus infection. Gene chip technology is quite valuable and practical in future clinic.
- Gene chip
- , Lamivudine
- , Gene mutation

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Detection of HBV Mutation Associated with Lamivudine By Gene Chips

XU Yi-ying ^, ,
REN Li-li

Corresponding author: XU Yi-ying,

1. Clinical Research Center, Shenzhen People’s Hospital, Shenzhen 518020,China

Abstract: In order to study the feasibility of gene chips technology in the detection of HBV mutation associated with lamivudine, we detected the mutation of HBV in peripheral blood of 30 patients treated with lamivudine for at least half a year by gene chips. The result was compared with that from direct sequencing. Both results are highly coincident. The rate reaches 100% while detecting single strain of virus infection, and 85% in multi-strains virus infection. Gene chip technology is quite valuable and practical in future clinic.