LI Bao-quan, PENG Jun, NIU Zhong-xiang* and JIANG Shi-jin. An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV[J]. Virologica Sinica, 2004, 19(6): 624-626.
Citation: LI Bao-quan, PENG Jun, NIU Zhong-xiang*, JIANG Shi-jin. An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV .VIROLOGICA SINICA, 2004, 19(6) : 624-626.

一种抗AIV共有独特型抗体具有AIV血凝素分子的内影象

  • 用纯化的鸡抗禽流感病毒(AIV) IgG作免疫原,通过单克隆抗体技术制备出1株分泌针对鸡抗AIV和兔抗AIV共有独特型抗体的杂交瘤细胞。竞争抑制试验、特异性检验和诱导产生血凝抑制抗体的功能实验证明,此抗体具有AIV血凝素分子的内影象。

An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV

  • One anti-idiotypic monoclonal antibody(a-Id Mab)was raised directed to both rabbit and chicken IgG against Avian influenza virus(AIV). The Mab was able to inhibit the binding of AIV to anti-AIV IgG and specific in binding anti-H9-subtype-AIV IgG. Another experiment demonstrated that the Mab might induce chicken to generate hemagglutination inhibition antibodies. These results indicated this anti-species-sharing-idiotypic antibody bore the internal image of hemagglutinin on AIV.

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    An Anti-species-sharing-idiotypic Antibody to AIV Bearing the Internal Image of Hemagglutinin on AIV

    • 1. College of Animal Sciences and Technology, Shandong Agricultural University, Taian 271018, China

    Abstract: One anti-idiotypic monoclonal antibody(a-Id Mab)was raised directed to both rabbit and chicken IgG against Avian influenza virus(AIV). The Mab was able to inhibit the binding of AIV to anti-AIV IgG and specific in binding anti-H9-subtype-AIV IgG. Another experiment demonstrated that the Mab might induce chicken to generate hemagglutination inhibition antibodies. These results indicated this anti-species-sharing-idiotypic antibody bore the internal image of hemagglutinin on AIV.

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