HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1  in a Xinjiang Uygur Population, China

XU Yan-ming; MA Jun; HONG Kun-xue; DENG Xiao-ling; LIU Yong-chao; RUAN Yu-hua; XING Hui; ZHANG Zhi-yuan; XU Xiao-hu; SHAO Yi-ming

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December 2005

XU Yan-ming, MA Jun, HONG Kun-xue, DENG Xiao-ling, LIU Yong-chao, RUAN Yu-hua, XING Hui, ZHANG Zhi-yuan, XU Xiao-hu and SHAO Yi-ming. HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China[J]. Virologica Sinica, 2005, 20(6): 594-599.

Citation: XU Yan-ming, MA Jun, HONG Kun-xue, DENG Xiao-ling, LIU Yong-chao, RUAN Yu-hua, XING Hui, ZHANG Zhi-yuan, XU Xiao-hu, SHAO Yi-ming. HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China .VIROLOGICA SINICA, 2005, 20(6) : 594-599.

中国新疆维族人群HLA-B等位基因与HIV-1感染易感性或抗性

许铭炎 ^1,2 ,
马军 ³ ,
洪坤学 ² ,
邓小玲 ¹ ,
刘永超 ² ,
阮玉华 ² ,
邢辉 ² ,
张远志 ³ ,
徐小虎 ¹ ,
邵一鸣 ^2*

1.
1.中国疾病预防控制中心性病艾滋病预防控制中心北京 2.广东汕头汕头大学医学院病原生物学教研室 3.新疆维吾尔族自治区疾病预防控制中心乌鲁木齐

摘要

通过对中国维吾尔族人群HLA-B等位基因的分布频率的研究,探讨HLA-B等位基因与HIV感染的易感或抵抗性的相关性。本研究用PCR-SSP的方法对新疆维吾尔族110例无相关的健康对照者(HIV阴性)和128例 HIV阳性感染者进行HLA-B等位基因分型。用POPGEN软件对健康对照者人群进行Hardy-Weinberg平衡检测,用卡方检验分析HLA-B等位基因在健康对照者和HIV阳性感染者频率分布的差异。在HIV-1阳性感染者中,B*4901等位基因频率显著性增加(B*4901:P=0．02．OR=3．06,95%CI=1．16～8．10)。而在健埭对照者中,B*40等位基因顿率增加具有统计意义(B*40:P=0．02．OR=0．39．95％CI=0．07～0．92)。由此可见,B* 4901等位基因可能与HIV-1感染的易感性有关,而B*40等位基因可能与与HIV-1感染的抵抗性有关。
- HIV感染
- , HLA-B抗原
- , 维吾尔族
- , 多态性

HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China

Abstract

Host genetic factors, such as human leukocyte antigen (HLA) alleles, are important in Human immunodeficiency virus ( HIV) infection and its progression to AIDS. HLA class I genes, especially highly polymorphic HLA-B genes, are involved in the activation of HLA-restricted cytotoxic T lymphocytes (CTLs) against HIV, and thus control susceptibility to or protect against this virus. The present study was aimed to determine the distribution of HLA-B alleles in the Chinese Uygur ethnic group and its association with HIV infection. One hundred ten healthy control (HIV negative) and 128 HIV positive Chinese Xinjiang Uygur ethnic individuals were used in this study. HLA typing for B allele was performed by polymerase chain reaction (PCR) with sequence-specific primers (SSP). Hardy-Weinberg equilibrium was calculated using POPGENE software for the healthy control group. The HLA-B frequency of each alleic was compared between the patients and the controls using the chi-square test. In HIV-1-pos-itive group, gene frequen
- HIV infection
- , HLA-B antigens
- , Uygur ethnic group
- , polymorphism

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

HLA-B Alleles Associated with Susceptibility or Resistance to Human Immunodeficiency Virus Type 1 in a Xinjiang Uygur Population, China

Abstract: Host genetic factors, such as human leukocyte antigen (HLA) alleles, are important in Human immunodeficiency virus ( HIV) infection and its progression to AIDS. HLA class I genes, especially highly polymorphic HLA-B genes, are involved in the activation of HLA-restricted cytotoxic T lymphocytes (CTLs) against HIV, and thus control susceptibility to or protect against this virus. The present study was aimed to determine the distribution of HLA-B alleles in the Chinese Uygur ethnic group and its association with HIV infection. One hundred ten healthy control (HIV negative) and 128 HIV positive Chinese Xinjiang Uygur ethnic individuals were used in this study. HLA typing for B allele was performed by polymerase chain reaction (PCR) with sequence-specific primers (SSP). Hardy-Weinberg equilibrium was calculated using POPGENE software for the healthy control group. The HLA-B frequency of each alleic was compared between the patients and the controls using the chi-square test. In HIV-1-pos-itive group, gene frequen