The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users

ZHANG Chun-tao; LI Ai-hua; SONG Ai-jing; XU Si-hong; WANG You-chun*

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December 2005

ZHANG Chun-tao, LI Ai-hua, SONG Ai-jing, XU Si-hong and WANG You-chun*. The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users[J]. Virologica Sinica, 2005, 20(6): 600-602.

Citation: ZHANG Chun-tao, LI Ai-hua, SONG Ai-jing, XU Si-hong, WANG You-chun*. The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users .VIROLOGICA SINICA, 2005, 20(6) : 600-602.

吸毒人群中HIV／HCV核酸和抗体关系的分析

1.
中国药品生物制品检定所北京

摘要

研究了高危人群中HIV/HCV核酸和抗体的关系。从新疆地区采集吸毒人群的血样,并对其进行HIV/ HCV核酸和抗体的检测。320例吸毒人员血浆样品中HCV抗体阳性为80．3％,HIV抗体阳性率为41．9％,HIV 和HCV共感染者为38．3％。HIV RNA与抗体的总符合率为98．8%,在186例HIV抗体阴性样品中可能有2例为HIV感染的窗口期。HCV抗体和HCV RNA的阳性符合率为92．6％,HCV RNA与HCV抗体的总符合率为 90．0％,以上结果说明在HIV／HCV的高流行区进行HIV／HCV核酸检测可以发现病毒感染的窗口期,而约8% 的HCV抗体阳性样品为病毒核酸阴性,也值得进一步研究。
- 丙型肝炎病毒
- , 人类免疫缺陷病毒
- , 核酸
- , 抗体
- , 核酸检测

The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users

Abstract

The objective of this study was to determine the relationship between the nucleic acid and antibody of HIV/HCV in a high-risk population. Plasma samples (320) were collected from drug users in Xinjiang and the nucleic acid and antibody of HIV/HCV were detected. A total of 38% of the subjects were positive for both HIV and HCV. The positive rate of HIV antibody was 41. 9%, and the relative coincident rate of HIV RNA and antibody was 98. 9%. HIV RNA was detected in 2 cases out of 186 HIV antibody negative cases. The positive rate of HCV antibody was 80. 3% , and the positive accordant rate of HCV RNA and antibody is 92. 6%, the general accordant rate of those is 90. 0%. These results indicated that HIV/HCV infection during the so-called window period can be found by the nucleic acid assay in high-risk areas, however, 8% of HCV antibody positive cases with negative HCV RNA requires further investigations.
- Hepatitis C virus （HCV）
- , Human immunodeficiency virus （HIV)
- , Nucleic acid
- , Antibody
- , Nucleic acid test （NAT）

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

The Relationship of the Nucleic Acid and Antibody of HIV/HCV Among Drug Users

Abstract: The objective of this study was to determine the relationship between the nucleic acid and antibody of HIV/HCV in a high-risk population. Plasma samples (320) were collected from drug users in Xinjiang and the nucleic acid and antibody of HIV/HCV were detected. A total of 38% of the subjects were positive for both HIV and HCV. The positive rate of HIV antibody was 41. 9%, and the relative coincident rate of HIV RNA and antibody was 98. 9%. HIV RNA was detected in 2 cases out of 186 HIV antibody negative cases. The positive rate of HCV antibody was 80. 3% , and the positive accordant rate of HCV RNA and antibody is 92. 6%, the general accordant rate of those is 90. 0%. These results indicated that HIV/HCV infection during the so-called window period can be found by the nucleic acid assay in high-risk areas, however, 8% of HCV antibody positive cases with negative HCV RNA requires further investigations.